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EFFECTS OF BINARY SOLVENT SYSTEM ON MORPHOLOGY OF PARTICLES

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Date Issued:
2015
Abstract/Description:
Recent advancements in cancer research has led to the synthesis of a new drug known as docetaxel. Meant to replace paclitaxel, its more natural counterpart whose ingredients are difficult to obtain, the drug is known to effectively treat a wide array of cancers, including breast cancer, ovarian cancer, and prostate cancer. The establishment of a synthetic alternative to paclitaxel has increased its bioavailability, thereby lowering the cost needed to utilize the drug. Still, the limiting factor in minimizing costs is the method in which the drug is processed. Current methods in drug processing have their limitations, which include the introduction of impurities and a low effective yield due to poor powder geometry. Thus, the goal of this study looks to explore a new way to process the drug in a more efficient manner. In this study, a new method for processing docetaxel is explored on in great detail. A more direct method of using electrospray deposition is utilized for the creation of monodisperse nanoparticles, with the main intention of increasing the efficiency at which the drug is processed and prepared for drug delivery to the patient by means of injection. A key feature in electrospray deposition is its ability to produce droplets that are sized homogenously. These droplets eventually evaporate at homogenous rates. These two concepts have been exploited to consistently produce nanoparticles of the cancer drug, which is made possible by the fact that the minimal variation in droplet sizes has easily translated to minimal variation in dry particle sizes. Compared to other methods of drug processing, one other benefit that electrospray deposition conveys is that through evaporation, virtually all impurities and unwanted foreign material are eliminated. Moreover, a binary solvent system is investigated in more detail in this study, so as to determine its effects on both the evaporation of the solvent and the diffusion of the drug into nanoparticles. From there, material and geometric properties of the electrospray nozzle were explored upon in great detail, with the main goal of being able to produce a cone jet that consistently dissociates into monodisperse droplets. At the same time, controllable properties of the electrospray atomizer were investigated and continuously modified. Modifications in both the components of the solution and the operating temperature were also considered to enhance both the electrospray deposition process and the geometry of the particles. Scanning electron microscopy (SEM) characterization is continuously utilized to determine suitability of results obtained in experiments. Ultimately, the goal of this study is to determine the ideal conditions (solvent ratios, flow rate, operating temperature, electrospray atomizer nozzle configurations, etc.) in which spherical docetaxel particles sized at 100-200 nm can be produced.
Title: EFFECTS OF BINARY SOLVENT SYSTEM ON MORPHOLOGY OF PARTICLES.
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Name(s): Besana, Patrick, Author
Deng, Weiwei, Committee Chair
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2015
Publisher: University of Central Florida
Language(s): English
Abstract/Description: Recent advancements in cancer research has led to the synthesis of a new drug known as docetaxel. Meant to replace paclitaxel, its more natural counterpart whose ingredients are difficult to obtain, the drug is known to effectively treat a wide array of cancers, including breast cancer, ovarian cancer, and prostate cancer. The establishment of a synthetic alternative to paclitaxel has increased its bioavailability, thereby lowering the cost needed to utilize the drug. Still, the limiting factor in minimizing costs is the method in which the drug is processed. Current methods in drug processing have their limitations, which include the introduction of impurities and a low effective yield due to poor powder geometry. Thus, the goal of this study looks to explore a new way to process the drug in a more efficient manner. In this study, a new method for processing docetaxel is explored on in great detail. A more direct method of using electrospray deposition is utilized for the creation of monodisperse nanoparticles, with the main intention of increasing the efficiency at which the drug is processed and prepared for drug delivery to the patient by means of injection. A key feature in electrospray deposition is its ability to produce droplets that are sized homogenously. These droplets eventually evaporate at homogenous rates. These two concepts have been exploited to consistently produce nanoparticles of the cancer drug, which is made possible by the fact that the minimal variation in droplet sizes has easily translated to minimal variation in dry particle sizes. Compared to other methods of drug processing, one other benefit that electrospray deposition conveys is that through evaporation, virtually all impurities and unwanted foreign material are eliminated. Moreover, a binary solvent system is investigated in more detail in this study, so as to determine its effects on both the evaporation of the solvent and the diffusion of the drug into nanoparticles. From there, material and geometric properties of the electrospray nozzle were explored upon in great detail, with the main goal of being able to produce a cone jet that consistently dissociates into monodisperse droplets. At the same time, controllable properties of the electrospray atomizer were investigated and continuously modified. Modifications in both the components of the solution and the operating temperature were also considered to enhance both the electrospray deposition process and the geometry of the particles. Scanning electron microscopy (SEM) characterization is continuously utilized to determine suitability of results obtained in experiments. Ultimately, the goal of this study is to determine the ideal conditions (solvent ratios, flow rate, operating temperature, electrospray atomizer nozzle configurations, etc.) in which spherical docetaxel particles sized at 100-200 nm can be produced.
Identifier: CFH0004872 (IID), ucf:45412 (fedora)
Note(s): 2015-12-01
B.S.M.E.
Engineering and Computer Science, Dept. of Mechanical, Materials and Aerospace Engineering
Bachelors
This record was generated from author submitted information.
Subject(s): particle engineering
docetaxel
paclitaxel
morphology
electrospray
electrospray deposition
SEM
diffusion
binary solvents
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFH0004872
Restrictions on Access: public
Host Institution: UCF

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