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DEVELOPMENT OF NOVEL DART™ TOFMS ANALYTICAL TECHNIQUES FOR THE IDENTIFICATION OF ORGANIC CONTAMINATION ON SPACEFLIGHT-RELATED SUBSTRATES AND AQUEOUS MEDIA

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Date Issued:
2009
Abstract/Description:
ABSTRACT Organic contamination on spaceflight hardware is an ongoing concern for spaceflight safety. In addition, for the goal of analyzing for possible evidence of extra-terrestrial life, it is necessary to consider the presence of terrestrial contamination. This paper will introduce and evaluate a new method using a direct analysis real time (DART™) ionization source paired with a high resolution time of flight mass spectrometer (TOFMS) for the determination of organic contamination involved in spaceflight hardware and ground support materials. This novel analytical technique has significant advantages over current methodologies. Materials analyzed in this study were historically considered as probable contaminants in spaceflight related substrates. A user determined library was generated due to the non-traditional mass spectra generated by the DART™. Continual improvement of analytical methods for the detection of trace levels of contaminants in potential drinking water sources is of extreme importance to both regulatory communities and concerned citizens. This paper will evaluate a novel analytical method using stir bar sorbtive (SBSE) extraction techniques combined with analysis with a DART™TOFMS. Compounds of interest will include several representative pharmaceutical contaminants of emerging concern listed in EPA method 1694. Optimal SBSE and DART™ experimental parameters will be investigated along with accuracy, precision, limits of detection and calibration linearity.
Title: DEVELOPMENT OF NOVEL DART™ TOFMS ANALYTICAL TECHNIQUES FOR THE IDENTIFICATION OF ORGANIC CONTAMINATION ON SPACEFLIGHT-RELATED SUBSTRATES AND AQUEOUS MEDIA.
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Name(s): Loftin, Kathleen, Author
Clausen, Christian, Committee Chair
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2009
Publisher: University of Central Florida
Language(s): English
Abstract/Description: ABSTRACT Organic contamination on spaceflight hardware is an ongoing concern for spaceflight safety. In addition, for the goal of analyzing for possible evidence of extra-terrestrial life, it is necessary to consider the presence of terrestrial contamination. This paper will introduce and evaluate a new method using a direct analysis real time (DART™) ionization source paired with a high resolution time of flight mass spectrometer (TOFMS) for the determination of organic contamination involved in spaceflight hardware and ground support materials. This novel analytical technique has significant advantages over current methodologies. Materials analyzed in this study were historically considered as probable contaminants in spaceflight related substrates. A user determined library was generated due to the non-traditional mass spectra generated by the DART™. Continual improvement of analytical methods for the detection of trace levels of contaminants in potential drinking water sources is of extreme importance to both regulatory communities and concerned citizens. This paper will evaluate a novel analytical method using stir bar sorbtive (SBSE) extraction techniques combined with analysis with a DART™TOFMS. Compounds of interest will include several representative pharmaceutical contaminants of emerging concern listed in EPA method 1694. Optimal SBSE and DART™ experimental parameters will be investigated along with accuracy, precision, limits of detection and calibration linearity.
Identifier: CFE0002714 (IID), ucf:48187 (fedora)
Note(s): 2009-08-01
Ph.D.
Sciences, Department of Chemistry
Doctorate
This record was generated from author submitted information.
Subject(s): chemistry
DART
direct analysis real time
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFE0002714
Restrictions on Access: public
Host Institution: UCF

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