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STUDY OF THE INTERACTIONS OF PROTEINS, CELLS AND TISSUE WITH BIOMATERIALS

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Date Issued:
2010
Abstract/Description:
Bioengineering is the application of engineering principles to address challenges in the fields of biology and medicine. Biomaterials play a major role in bioengineering. This work employs a three level approach to study the various interactions of biomaterials with proteins, cells and tissue in-vitro. In the first study, we qualitatively and quantitatively analyzed the process of protein adsorption of two enzymes to two different surface chemistries, which are commonly used in the field. In the second study, we attempted to engineer a tissue construct to build a biocompatible interface between a titanium substrate and human skin. In the third study, an in-vitro model of the motoneuron-muscle part of the stretch reflex arc circuit was developed. Using a novel silicon based micro-cantilever device, muscle contraction dynamics were measured and have shown the presence of a functional neuro-muscular junction (NMJ). These studies have potential applications in the rational design of biomaterials used for biosensors and other implantable devices, in the development of a functional prosthesis and as a high-throughput drug-screening platform to study various neuro-muscular disorders.
Title: STUDY OF THE INTERACTIONS OF PROTEINS, CELLS AND TISSUE WITH BIOMATERIALS.
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Name(s): Bhalkikar, Abhijeet, Author
Hickman, James, Committee Chair
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2010
Publisher: University of Central Florida
Language(s): English
Abstract/Description: Bioengineering is the application of engineering principles to address challenges in the fields of biology and medicine. Biomaterials play a major role in bioengineering. This work employs a three level approach to study the various interactions of biomaterials with proteins, cells and tissue in-vitro. In the first study, we qualitatively and quantitatively analyzed the process of protein adsorption of two enzymes to two different surface chemistries, which are commonly used in the field. In the second study, we attempted to engineer a tissue construct to build a biocompatible interface between a titanium substrate and human skin. In the third study, an in-vitro model of the motoneuron-muscle part of the stretch reflex arc circuit was developed. Using a novel silicon based micro-cantilever device, muscle contraction dynamics were measured and have shown the presence of a functional neuro-muscular junction (NMJ). These studies have potential applications in the rational design of biomaterials used for biosensors and other implantable devices, in the development of a functional prosthesis and as a high-throughput drug-screening platform to study various neuro-muscular disorders.
Identifier: CFE0003347 (IID), ucf:48433 (fedora)
Note(s): 2010-08-01
M.S.
Engineering and Computer Science, School of Electrical Engineering and Computer Science
Masters
This record was generated from author submitted information.
Subject(s): Proteins
Cells
Tissue
Biomaterials
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFE0003347
Restrictions on Access: public 2010-07-01
Host Institution: UCF

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