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THE ORIGINS OF LACTASE PERSISTENCE AND ONGOING CONVERGENT EVOLUTION

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Date Issued:
2011
Abstract/Description:
As a primary factor in human evolution, natural selection is an important component of genetic research. Studies of lactase persistence suggest that positive selection has played a powerful role in the adaptation to a lifelong consumption of fresh milk. Using multiple research studies of lactase persistence and suspected corresponding single nucleotide genetic polymorphisms, this study combines data sources to determine whether evidence exists for natural selection of a specific cytosine-to-thymine genetic mutation located 13,910 base pairs (T-13910) upstream from the lactase gene. This polymorphism has potential to be a causal element for lactase persistence, and data suggest that natural selection has played a role in the rising frequency and distribution of this allele, if only in some regions. European and neighboring regions appear to have the highest frequencies with little or no frequency in Asia, Africa and Indonesia; however the presence of lactase persistence in those areas suggests convergent evolution may be occurring on a phenotypic level. To examine this possibility several other identified polymorphisms in the same region as the T-13910 will be included in this study.
Title: THE ORIGINS OF LACTASE PERSISTENCE AND ONGOING CONVERGENT EVOLUTION.
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Name(s): Keller, Beth, Author
McIntyre, Matthew, Committee Chair
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2011
Publisher: University of Central Florida
Language(s): English
Abstract/Description: As a primary factor in human evolution, natural selection is an important component of genetic research. Studies of lactase persistence suggest that positive selection has played a powerful role in the adaptation to a lifelong consumption of fresh milk. Using multiple research studies of lactase persistence and suspected corresponding single nucleotide genetic polymorphisms, this study combines data sources to determine whether evidence exists for natural selection of a specific cytosine-to-thymine genetic mutation located 13,910 base pairs (T-13910) upstream from the lactase gene. This polymorphism has potential to be a causal element for lactase persistence, and data suggest that natural selection has played a role in the rising frequency and distribution of this allele, if only in some regions. European and neighboring regions appear to have the highest frequencies with little or no frequency in Asia, Africa and Indonesia; however the presence of lactase persistence in those areas suggests convergent evolution may be occurring on a phenotypic level. To examine this possibility several other identified polymorphisms in the same region as the T-13910 will be included in this study.
Identifier: CFE0003608 (IID), ucf:48890 (fedora)
Note(s): 2011-05-01
M.A.
Sciences, Department of Anthropology
Masters
This record was generated from author submitted information.
Subject(s): lactase
persistence
nonpersistence
lactose intolerance
convergent evolution
dairy
pastoralism
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFE0003608
Restrictions on Access: campus 2012-04-01
Host Institution: UCF

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