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- Title
- A FLUID STRUCTURE INTERACTION MODEL OF INTRACORONARY ATHEROSCLEROTIC PLAQUE RUPTURE.
- Creator
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TEUMA-MELAGO, Eric, Ilegbusi, Olusegun, University of Central Florida
- Abstract / Description
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Plaque rupture with superimposed thrombosis is the primary cause of acute coronary syndromes of unstable angina, myocardial infarction and sudden death. Although intensive studies in the past decade have shed light on the mechanism that causes unstable atheroma, none has directly addressed the clinical observation that most myocardial infarction (MI) patients have moderate stenoses (less than 50%). Considering the important role the arterial wall compliance and pulsitile blood flow play in...
Show morePlaque rupture with superimposed thrombosis is the primary cause of acute coronary syndromes of unstable angina, myocardial infarction and sudden death. Although intensive studies in the past decade have shed light on the mechanism that causes unstable atheroma, none has directly addressed the clinical observation that most myocardial infarction (MI) patients have moderate stenoses (less than 50%). Considering the important role the arterial wall compliance and pulsitile blood flow play in atheroma rupture, fluid-structure interaction (FSI) phenomenon has been of interest in recent studies. In this thesis, the impact is investigated numerically of coupled blood flow and structural dynamics on coronary plaque rupture. The objective is to determine a unique index that can be used to characterize plaque rupture potential. The FSI index, developed in this study for the first time derives from the theory of buckling of thin-walled cylinder subjected to radial pressure. Several FSI indices are first defined by normalizing the predicted hemodynamic endothelial shear stress by the structural stresses, specifically, by the maximum principal stress (giving the ratio ), and the Von Mises stress (giving the ratio ). The predicted at the location of maximum (i.e { }) denoted , is then chosen to characterize plaque rupture through systematic investigation of a variety of plaque characteristics and simulated patient conditions. The conditions investigated include varying stenosis levels ranging from 20% to 70%, blood pressure drop ranging from 3125 Pa/m to 9375 Pa/m, fibrous cap thickness ranging from to , lipid pool location ranging from the leading to the trailing edge of plaque, lipid pool volume relative to stenosis volume ranging from 24% to 80%, Calcium volume relative to stenosis volume ranging from 24% to 80% and arterial remodeling. The predicted varies with the stenosis severity and indicates that the plaques investigated are prone to rupture at approximately 40-45% stenosis levels. It predicts that high pressure significantly lowers the threshold stenosis rate for plaque rupture. In addition, the plaque potential to rupture increases for relatively thin fibrous cap, lipid core located near the leading plaque shoulder, and dramatically for relative lipid pool volume above 60%. However, calcium deposit has marginal effect on plaque rupture. Overall, the predicted results are consistent with clinical observations, indicating that the has the potential to characterize plaque rupture when properly established. In the appendix, the unsteady flow in a collapsible tube model of a diseased artery is solved analytically. The novelty of our approach is that the set of governing equations is reduced to a single integro-differential equation in the transient state. The equation was solved using the finite difference method to obtain the pressure and compliant wall behavior. The analytical approach is less computer-intensive than solving the full set of governing equations. The predicted membrane deflection is quite large at low inlet velocity, suggesting possible approach to breakdown in equilibrium. As the transmural pressure increases with wall deflection, bulges appear at the ends of the membrane indicating critical stage of stability, consistent with previous studies. An increase in wall thickness reduces the wall deflection and ultimately results in its collapse. The collapse is due to breakdown in the balance of wall governing equation. An increase in internal pressure is required to maintain membrane stability.
Show less - Date Issued
- 2006
- Identifier
- CFE0001471, ucf:47084
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0001471
- Title
- Combustion Synthesis and Characterization of Porous NiTi Intermetallic For Structural Application.
- Creator
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Vanterpool, Jessica, Ilegbusi, Olusegun, Gou, Jihua, Nicholson, David, University of Central Florida
- Abstract / Description
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This thesis describes experimental investigation of thermal and combustion phenomena as well as structure for self- propagating combustion synthesis of porous Ni - Ti intermetallic aimed for structural biomedical application. The control parameters for the porosity distribution have been investigated experimentally through varying the preheat temperature, initial porosity, initial elemental particle size, and applied pressure during the fabrication process. Ni and Ti elemental powders are...
Show moreThis thesis describes experimental investigation of thermal and combustion phenomena as well as structure for self- propagating combustion synthesis of porous Ni - Ti intermetallic aimed for structural biomedical application. The control parameters for the porosity distribution have been investigated experimentally through varying the preheat temperature, initial porosity, initial elemental particle size, and applied pressure during the fabrication process. Ni and Ti elemental powders are mixed using a 1:1 ratio. The mixture is compressed using several different compression forces to produce cylindrical samples of 1.1 cm diameter and 2-3cm length, with initial porosity ranging from 30% to 40%. The samples are preheated to various initial temperatures and ignited from the top surface such that the flame propagates axially downwards. The combustion reaction is recorded with a motion camera. An infrared sensor is used to record the temperature profile during the combustion process. The samples are then cut using a diamond saw in both longitudinal and transverse directions. Image analysis software is then used to analyze the porosity distribution in each sample.
Show less - Date Issued
- 2013
- Identifier
- CFE0004768, ucf:49803
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0004768
- Title
- Meshless Direct Numerical Simulation of Turbulent Incompressible Flows.
- Creator
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Vidal Urbina, Andres, Kassab, Alain, Kumar, Ranganathan, Ilegbusi, Olusegun, Divo, Eduardo, University of Central Florida
- Abstract / Description
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A meshless direct pressure-velocity coupling procedure is presented to perform Direct Numerical Simulations (DNS) and Large Eddy Simulations (LES) of turbulent incompressible flows in regular and irregular geometries. The proposed method is a combination of several efficient techniques found in different Computational Fluid Dynamic (CFD) procedures and it is a major improvement of the algorithm published in 2007 by this author. This new procedure has very low numerical diffusion and some...
Show moreA meshless direct pressure-velocity coupling procedure is presented to perform Direct Numerical Simulations (DNS) and Large Eddy Simulations (LES) of turbulent incompressible flows in regular and irregular geometries. The proposed method is a combination of several efficient techniques found in different Computational Fluid Dynamic (CFD) procedures and it is a major improvement of the algorithm published in 2007 by this author. This new procedure has very low numerical diffusion and some preliminary calculations with 2D steady state flows show that viscous effects become negligible faster that ever predicted numerically.The fundamental idea of this proposal lays on several important inconsistencies found in three of the most popular techniques used in CFD, segregated procedures, streamline-vorticity formulation for 2D viscous flows and the fractional-step method, very popular in DNS/LES.The inconsistencies found become important in elliptic flows and they might lead to some wrong solutions if coarse grids are used. In all methods studied, the mathematical basement was found to be correct in most cases, but inconsistencies were found when writing the boundary conditions. In all methods analyzed, it was found that it is basically impossible to satisfy the exact set of boundary conditions and all formulations use a reduced set, valid for parabolic flows only.For example, for segregated methods, boundary condition of normal derivative for pressure zero is valid only in parabolic flows. Additionally, the complete proposal for mass balance correction is right exclusively for parabolic flows.In the streamline-vorticity formulation, the boundary conditions normally used for the streamline function, violates the no-slip condition for viscous flow. Finally, in the fractional-step method, the boundary condition for pseudo-velocity implies a zero normal derivative for pressure in the wall (correct in parabolic flows only) and, when the flows reaches steady state, the procedure does not guarantee mass balance.The proposed procedure is validated in two cases of 2D flow in steady state, backward-facing step and lid-driven cavity. Comparisons are performed with experiments and excellent agreement was obtained in the solutions that were free from numerical instabilities.A study on grid usage is done. It was found that if the discretized equations are written in terms of a local Reynolds number, a strong criterion can be developed to determine, in advance, the grid requirements for any fluid flow calculation.The 2D-DNS on parallel plates is presented to study the basic features present in the simulation of any turbulent flow. Calculations were performed on a short geometry, using a uniform and very fine grid to avoid any numerical instability. Inflow conditions were white noise and high frequency oscillations. Results suggest that, if no numerical instability is present, inflow conditions alone are not enough to sustain permanently the turbulent regime.Finally, the 2D-DNS on a backward-facing step is studied. Expansion ratios of 1.14 and 1.40 are used and calculations are performed in the transitional regime. Inflow conditions were white noise and high frequency oscillations. In general, good agreement is found on most variables when comparing with experimental data.
Show less - Date Issued
- 2015
- Identifier
- CFE0005733, ucf:50148
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0005733
- Title
- Inverse-Consistent Determination of Young's Modulus of Human Lung.
- Creator
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Seyfi Noferest, Behnaz, Ilegbusi, Olusegun, Santhanam, Anand, Kassab, Alain, Moslehy, Faissal, University of Central Florida
- Abstract / Description
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Human lung undergoes respiration-induced deformation due to sequential inhalation and exhalation. Accurate determination of lung deformation is crucial for tumor localization and targeted radiotherapy in patients with lung cancer. Numerical modeling of human lung dynamics based on underlying physics and physiology enables simulation and virtual visualization of lung deformation. Dynamical modeling is numerically complicated by the lack of information on lung elastic behavior, structural...
Show moreHuman lung undergoes respiration-induced deformation due to sequential inhalation and exhalation. Accurate determination of lung deformation is crucial for tumor localization and targeted radiotherapy in patients with lung cancer. Numerical modeling of human lung dynamics based on underlying physics and physiology enables simulation and virtual visualization of lung deformation. Dynamical modeling is numerically complicated by the lack of information on lung elastic behavior, structural heterogeneity as well as boundary constrains. This study integrates physics-based modeling and image-based data acquisition to develop the patient-specific biomechanical model and consequently establish the first consistent Young's modulus (YM) of human lung. This dissertation has four major components: (i) develop biomechanical model for computation of the flow and deformation characteristics that can utilize subject-specific, spatially-dependent lung material property; (ii) develop a fusion algorithm to integrate deformation results from a deformable image registration (DIR) and physics-based modeling using the theory of Tikhonov regularization; (iii) utilize fusion algorithm to establish unique and consistent patient specific Young's modulus and; (iv) validate biomechanical model utilizing established patient-specific elastic property with imaging dataThe simulation is performed on three dimensional lung geometry reconstructed from four-dimensional computed tomography (4DCT) dataset of human subjects. The heterogeneous Young's modulus is estimated from a linear elastic deformation model with the same lung geometry and 4D lung DIR. The biomechanical model adequately predicts the spatio-temporal lung deformation, consistent with data obtained from imaging. The accuracy of the numerical solution is enhanced through fusion with the imaging data beyond the classical comparison of the two sets of data. Finally, the fused displacement results are used to establish unique and consistent patient-specific elastic property of the lung.
Show less - Date Issued
- 2015
- Identifier
- CFE0006391, ucf:51512
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0006391
- Title
- Modeling and Spray Pyrolysis Processing of Mixed Metal Oxide Nano-Composite Gas Sensor Films.
- Creator
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Khatami, Seyed Mohammad Navid, Ilegbusi, Olusegun, Deng, Weiwei, Kassab, Alain, Coffey, Kevin, Divo, Eduardo, University of Central Florida
- Abstract / Description
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The role of sensor technology is obvious in improvement and optimization of many industrial processes. The sensor films, which are considered the core of chemical sensors, have the capability to detect the presence and concentration of a specific chemical substance. Such sensor films achieve selectivity by detecting the interaction of the specific chemical substance with the sensor material through selective binding, adsorption and permeation of analyte. This research focuses on development...
Show moreThe role of sensor technology is obvious in improvement and optimization of many industrial processes. The sensor films, which are considered the core of chemical sensors, have the capability to detect the presence and concentration of a specific chemical substance. Such sensor films achieve selectivity by detecting the interaction of the specific chemical substance with the sensor material through selective binding, adsorption and permeation of analyte. This research focuses on development and verification of a comprehensive mathematical model of mixed metal oxide thin film growth using spray pyrolysis technique (SPT). An experimental setup is used to synthesize mixed metal oxide films on a heated substrate. The films are analyzed using a variety of characterization tools. The results are used to validate the mathematical model. There are three main stages to achieve this goal: 1) A Lagrangian-Eulerian method is applied to develop a CFD model of atomizing multi-component solution. The model predicts droplet characteristics in flight, such as spatial distribution of droplet size and concentration. 2) Upon reaching the droplets on the substrate, a mathematical model of multi-phase transport and chemical reaction phenomena in a single droplet is developed and used to predict the deposition of thin film. The various stages of droplet morphology associated with surface energy and evaporation are predicted. 3) The processed films are characterized for morphology and chemical composition (SEM, XPS) and the data are used to validate the models as well as investigate the influence of process parameters on the structural characteristics of mixed metal oxide films. The structural characteristics are investigated of nano structured thin films comprising of ZnO, SnO2, ZnO+In2O3 and SnO2+In2O3 composites. The model adequately predicts the size distribution and film thickness when the nanocrystals are well-structured at the controlled temperature and concentration.
Show less - Date Issued
- 2014
- Identifier
- CFE0005817, ucf:50048
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0005817
- Title
- Mathematical and Computational Methods for Freeform Optical Shape Description.
- Creator
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Kaya, Ilhan, Foroosh, Hassan, Rolland, Jannick, Turgut, Damla, Thompson, Kevin, Ilegbusi, Olusegun, University of Central Florida
- Abstract / Description
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Slow-servo single-point diamond turning as well as advances in computer controlled small lap polishing enable the fabrication of freeform optics, specifically, optical surfaces for imaging applications that are not rotationally symmetric. Freeform optical elements will have a profound importance in the future of optical technology. Orthogonal polynomials added onto conic sections have been extensively used to describe optical surface shapes. The optical testing industry has chosen to...
Show moreSlow-servo single-point diamond turning as well as advances in computer controlled small lap polishing enable the fabrication of freeform optics, specifically, optical surfaces for imaging applications that are not rotationally symmetric. Freeform optical elements will have a profound importance in the future of optical technology. Orthogonal polynomials added onto conic sections have been extensively used to describe optical surface shapes. The optical testing industry has chosen to represent the departure of a wavefront under test from a reference sphere in terms of orthogonal ?-polynomials, specifically Zernike polynomials. Various forms of polynomials for describing freeform optical surfaces may be considered, however, both in optical design and in support of fabrication. More recently, radial basis functions were also investigated for optical shape description. In the application of orthogonal ?-polynomials to optical freeform shape description, there are important limitations, such as the number of terms required as well as edge-ringing and ill-conditioning in representing the surface with the accuracy demanded by most stringent optics applications. The first part of this dissertation focuses upon describing freeform optical surfaces with ? polynomials and shows their limitations when including higher orders together with possible remedies. We show that a possible remedy is to use edge clustered-fitting grids. Provided different grid types, we furthermore compared the efficacy of using different types of ? polynomials, namely Zernike and gradient orthogonal Q polynomials. In the second part of this thesis, a local, efficient and accurate hybrid method is developed in order to greatly reduce the order of polynomial terms required to achieve higher level of accuracy in freeform shape description that were shown to require thousands of terms including many higher order terms under prior art. This comes at the expense of multiple sub-apertures, and as such computational methods may leverage parallel processing. This new method combines the assets of both radial basis functions and orthogonal phi-polynomials for freeform shape description and is uniquely applicable across any aperture shape due to its locality and stitching principles. Finally in this thesis, in order to comprehend the possible advantages of parallel computing for optical surface descriptions, the benefits of making an effective use of impressive computational power offered by multi-core platforms for the computation of ?-polynomials are investigated. The ?-polynomials, specifically Zernike and gradient orthogonal Q-polynomials, are implemented with a set of recurrence based parallel algorithms on Graphics Processing Units (GPUs). The results show that more than an order of magnitude speedup is possible in the computation of ?-polynomials over a sequential implementation if the recurrence based parallel algorithms are adopted.
Show less - Date Issued
- 2013
- Identifier
- CFE0005012, ucf:49993
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0005012
- Title
- Biomechanical Models of Human Upper and Tracheal Airway Functionality.
- Creator
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Kuruppumullage, Don Nadun, Ilegbusi, Olusegun, Kassab, Alain, Moslehy, Faissal, Santhanam, Anand, Mansy, Hansen, Hoffman Ruddy, Bari, University of Central Florida
- Abstract / Description
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The respiratory tract, in other words, the airway, is the primary airflow path for several physiological activities such as coughing, breathing, and sneezing. Diseases can impact airway functionality through various means including cancer of the head and neck, Neurological disorders such as Parkinson's disease, and sleep disorders and all of which are considered in this study. In this dissertation, numerical modeling techniques were used to simulate three distinct airway diseases: a weak...
Show moreThe respiratory tract, in other words, the airway, is the primary airflow path for several physiological activities such as coughing, breathing, and sneezing. Diseases can impact airway functionality through various means including cancer of the head and neck, Neurological disorders such as Parkinson's disease, and sleep disorders and all of which are considered in this study. In this dissertation, numerical modeling techniques were used to simulate three distinct airway diseases: a weak cough leading to aspiration, upper airway patency in obstructive sleep apnea, and tongue cancer in swallow disorders. The work described in this dissertation, therefore, divided into three biomechanical models, of which fluid and particulate dynamics model of cough is the first. Cough is an airway protective mechanism, which results from a coordinated series of respiratory, laryngeal, and pharyngeal muscle activity. Patients with diminished upper airway protection often exhibit cough impairment resulting in aspiration pneumonia. Computational Fluid Dynamics (CFD) technique was used to simulate airflow and penetrant behavior in the airway geometry reconstructed from Computed Tomography (CT) images acquired from participants. The second study describes Obstructive Sleep Apnea (OSA) and the effects of dilator muscular activation on the human retro-lingual airway in OSA. Computations were performed for the inspiration stage of the breathing cycle, utilizing a fluid-structure interaction (FSI) method to couple structural deformation with airflow dynamics. The spatiotemporal deformation of the structures surrounding the airway wall was predicted and found to be in general agreement with observed changes in luminal opening and the distribution of airflow from upright to supine posture. The third study describes the effects of cancer of the tongue base on tongue motion during swallow. A three-dimensional biomechanical model was developed and used to calculate the spatiotemporal deformation of the tongue under a sequence of movements which simulate the oral stage of swallow.
Show less - Date Issued
- 2018
- Identifier
- CFE0007034, ucf:51986
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0007034
