Current Search: Riddlesworth, Tonya (x)
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Title
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Estimation for the Cox Model with Various Types of Censored Data.
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Creator
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Riddlesworth, Tonya, Ren, Joan, Mohapatra, Ram, Richardson, Gary, Ni, Liqiang, Schott, James, University of Central Florida
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Abstract / Description
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In survival analysis, the Cox model is one of the most widely used tools. However, up to now there has not been any published work on the Cox model with complicated types of censored data, such as doubly censored data, partly-interval censored data, etc., while these types of censored data have been encountered in important medical studies, such as cancer, heart disease, diabetes, etc. In this dissertation, we first derive the bivariate nonparametric maximum likelihood estimator (BNPMLE) Fn(t...
Show moreIn survival analysis, the Cox model is one of the most widely used tools. However, up to now there has not been any published work on the Cox model with complicated types of censored data, such as doubly censored data, partly-interval censored data, etc., while these types of censored data have been encountered in important medical studies, such as cancer, heart disease, diabetes, etc. In this dissertation, we first derive the bivariate nonparametric maximum likelihood estimator (BNPMLE) Fn(t,z) for joint distribution function Fo(t,z) of survival time T and covariate Z, where T is subject to right censoring, noting that such BNPMLE Fn has not been studied in statistical literature. Then, based on this BNPMLE Fn we derive empirical likelihood-based (Owen, 1988) confidence interval for the conditional survival probabilities, which is an important and difficult problem in statistical analysis, and also has not been studied in literature. Finally, with this BNPMLE Fn as a starting point, we extend the weighted empirical likelihood method (Ren, 2001 and 2008a) to the multivariate case, and obtain a weighted empirical likelihood-based estimation method for the Cox model. Such estimation method is given in a unified form, and is applicable to various types of censored data aforementioned.
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Date Issued
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2011
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Identifier
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CFE0004158, ucf:49051
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Format
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Document (PDF)
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PURL
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http://purl.flvc.org/ucf/fd/CFE0004158
