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THE EFFECTS OF A STRUCTURED LIFESTYLE INTERVENTION PROGRAM IN CONJUNCTION WITH DIETARY SUPPLEMENTATION ON WEIGHT LOSS AND RISK FACTORS FOR THE METABOLIC SYNDROME
Title
THE EFFECTS OF A STRUCTURED LIFESTYLE INTERVENTION PROGRAM IN CONJUNCTION WITH DIETARY SUPPLEMENTATION ON WEIGHT LOSS AND RISK FACTORS FOR THE METABOLIC SYNDROME.
Creator
Zukley, Linda, Angelopoulos, Theodore, University of Central Florida
Abstract / Description
The objective of this study was to determine the effects of a structured weight loss program that included hypocaloric diet, exercise and dietary supplementation, on weight loss, metabolic syndrome risk factors and antioxidant levels in healthy overweight and obese females. Thirty-seven healthy overweight and obese women (BMI 29.5 ± 2.3 kg/m2, 41.1 ± 7.1 yrs) participated in this study. The subjects were randomized into one of two groups: an exercise, hypocaloric diet and antioxidant...
Show moreThe objective of this study was to determine the effects of a structured weight loss program that included hypocaloric diet, exercise and dietary supplementation, on weight loss, metabolic syndrome risk factors and antioxidant levels in healthy overweight and obese females. Thirty-seven healthy overweight and obese women (BMI 29.5 ± 2.3 kg/m2, 41.1 ± 7.1 yrs) participated in this study. The subjects were randomized into one of two groups: an exercise, hypocaloric diet and antioxidant supplement (LifePak®; LSANT group, n=20) or an exercise, hypocaloric diet and appetite suppression supplement (HTP Complex® and TēGreen®; LSAS group, n=17). A significant weight loss occurred in both groups after 12 weeks (LSANT: -2.8 ± 2.8 kg and LSAS: -4.3 ± 2.7 kg, p<0.001). Body fat mass, percent body fat, and waist circumference significantly improved in both groups (p<0.05). No significant difference was found between the groups for weight loss (p>0.05). However, a significant difference was found between the groups for body fat mass (LSANT: -1.8 ± 2.6 kg; LSAS: -3.4 ± 2.4 kg, p ≤ 0.05). Glucose, insulin and insulin resistance (HOMA-IR) were significantly decreased in the LSAS group (glucose: -5.0 ± 6.8 mg/dl, p=0.008; insulin: -2.6 ± 3.8 uIU/dl, p=0.013; and HOMA-IR: -0.7 ± 1.0, p=0.012) but not in the LSANT group (p>0.05). There were no significant differences (p>0.05) observed within or between the groups for cholesterol, triglycerides or LDL-c. HDL-c decreased significantly in the LSANT group (-2.9 ± 5.3 mg/dl, p=0.024) but not in the LSAS group (p>0.05). Skin carotenoid scores (SCS) increased significantly within the LSANT group (LSANT: 10950 ± 8395 SCS, p<0.001) but not the LSAS group (p>0.05). Lifestyle intervention that involves a structured hypocaloric diet and increased physical activity results in weight loss and improvements in body composition. However, supplementation with an appetite suppressant (HTP Complex®) did not enhance weight loss beyond what was achieved with a structured lifestyle intervention. Antioxidant supplementation may be of benefit during a weight loss program that incorporates physical activity and a low energy diet.
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Date Issued
2007
Identifier
CFE0001815, ucf:47348
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0001815
Cardiac Autonomic Control in Patients with Metabolic Syndrome
Title
Cardiac Autonomic Control in Patients with Metabolic Syndrome.
Creator
Mitchell, Jonathan, Cassisi, Jeffrey, Bedwell, Jeffrey, Beidel, Deborah, University of Central Florida
Abstract / Description
Metabolic syndrome (MetS) encompasses metabolic abnormalities that substantially increase risk for chronic illnesses. MetS and stress are closely related; the pathophysiology of MetS involves dysregulated stress response in both the physiological and psychological domains. In an effort to further clarify the relationship between metabolic abnormalities and autonomic dysregulation, we used ambulatory impedance cardiography to examine indicators of cardiac autonomic control (CAC) in a sample of...
Show moreMetabolic syndrome (MetS) encompasses metabolic abnormalities that substantially increase risk for chronic illnesses. MetS and stress are closely related; the pathophysiology of MetS involves dysregulated stress response in both the physiological and psychological domains. In an effort to further clarify the relationship between metabolic abnormalities and autonomic dysregulation, we used ambulatory impedance cardiography to examine indicators of cardiac autonomic control (CAC) in a sample of 50 adult primary care patients with and without MetS. Indices of sympathetic and parasympathetic influences on cardiovascular functioning were assessed in the context of psychological stressors and compared across experimental groups and examined in relation to self-reported health measures. Primary results suggest that while our experimental groups did not differ significantly on baseline measures, patterns of responses to experimentally induced stressors were largely consistent with our predictions, and demonstrate that individuals with MetS responded to stress cues with more maladaptive CAC scores. Moreover, in line with previous work, we found that elements of CAC in our sample were predictive of both cardiovascular disease and self-reported environmental quality of life. Overall, our results suggest that maladaptive physiological manifestations of the stress response are evident among individuals with MetS and may also be related to long-term health outcomes. The present study carries implications for both evaluation and assessment as well as treatment delivery and monitoring. In addition, the ambulatory nature of data collection demonstrated here supports trends toward mHealth and related initiatives in emerging modes of healthcare delivery.
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Date Issued
2016
Identifier
CFE0006359, ucf:51519
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0006359