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COARSE GRAINED MONTE CARLO SIMULATION OF THE SELF-ASSEMBLY OF THEHIV-1 CAPSID PROTEIN

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Date Issued:
2014
Abstract/Description:
In this study, a Monte Carlo simulation was designed to observe the self-assembly of the HIV-1 capsid protein. The simulation allowed a coarse grained model of the capsid protein with defined interaction sites to move freely in three dimensions using the Metropolis criterion. Observations were made as to which parameters affected the assembly the process. The ways in which the assembly were affected were also noted. It was found that proper dimerization of the capsid protein was necessary in order for the lattice to form properly. It was also found that a strong trimeric interface could be responsible for double-layered assemblies. Further studies may be conducted by further varying of parameters or reworking the dynamics of the simulation. The possible causes of curvature within the assembly still need to be researched further.
Title: COARSE GRAINED MONTE CARLO SIMULATION OF THE SELF-ASSEMBLY OF THEHIV-1 CAPSID PROTEIN.
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Name(s): Weber, Jeffrey, Author
Chen, Bo, Committee Chair
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2014
Publisher: University of Central Florida
Language(s): English
Abstract/Description: In this study, a Monte Carlo simulation was designed to observe the self-assembly of the HIV-1 capsid protein. The simulation allowed a coarse grained model of the capsid protein with defined interaction sites to move freely in three dimensions using the Metropolis criterion. Observations were made as to which parameters affected the assembly the process. The ways in which the assembly were affected were also noted. It was found that proper dimerization of the capsid protein was necessary in order for the lattice to form properly. It was also found that a strong trimeric interface could be responsible for double-layered assemblies. Further studies may be conducted by further varying of parameters or reworking the dynamics of the simulation. The possible causes of curvature within the assembly still need to be researched further.
Identifier: CFH0004618 (IID), ucf:45316 (fedora)
Note(s): 2014-05-01
B.S.
Sciences, Dept. of Physics
Bachelors
This record was generated from author submitted information.
Subject(s): HIV HIV-1 capsid protein molecular dynamics monte carlo
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFH0004618
Restrictions on Access: public
Host Institution: UCF

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