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VITAMIN D CLINICAL RELEVANCE IN THE RECOVERY FROM TRAUMATIC BRAIN INJURY AMONG THE MILITARY POPULATION
| Title: | VITAMIN D CLINICAL RELEVANCE IN THE RECOVERY FROM TRAUMATIC BRAIN INJURY AMONG THE MILITARY POPULATION. |
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| Name(s): |
Colon, Yuisa M., Author Chase, Susan K., Committee Chair University of Central Florida, Degree Grantor |
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| Type of Resource: | text | |
| Date Issued: | 2016 | |
| Publisher: | University of Central Florida | |
| Language(s): | Engilsh | |
| Abstract/Description: | Background: Traumatic brain injury (TBI) still remains a difficult disorder to treat. TBI has been associated to chronic neuroinflammation and a high risk for neurodegenerative disorders. Since 2001 between ten to twenty percent of all deployed military members have suffered a combat-related TBI. Nearly twenty to thirty percent of those will experience chronic cognitive, behavioral and somatic symptoms after suffering a TBI. Methods: The objective of this review is to evaluate current literature examining vitamin D as a neurosteroid with protective properties and its clinical relevance after traumatic brain injury. Vitamin D is known to participate in neurobiological processes and genomic regulation in the brain. Clinical and laboratory findings support that vitamin D modulates the immune responses to trauma, diminishes oxidative and toxic damage, and inhibiting activation and progression of the neuroinflammation. Inadequate levels of vitamin D have been identified as a common risk factor for many neurological disorders and have been linked to poorer recovery. Results: This review found compelling evidence to support that the pathology of TBI is closely associated with neuroprotective mechanisms of vitamin D. Low vitamin D levels are common among US active duty military and veterans. The findings strongly suggest that optimizing vitamin D prior to injury could improve the recovery for military members after experiencing a TBI. Vitamin D ameliorates brain damage by modulating neuroinflammation, improving cell survival and down-regulating mechanisms involved in the progression of cell damage following a TBI. However, further studies are needed to evaluate the effects of vitamin D optimization in TBI outcomes. | |
| Identifier: | CFH2000097 (IID), ucf:45536 (fedora) | |
| Note(s): |
2016-08-01 B.S.N. College of Nursing, Nursing Bachelors This record was generated from author submitted information. |
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| Subject(s): |
vitamin D calcitriol 25OHD3 low vitamin D neuroprotection traumatic brain injury TBI |
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| Persistent Link to This Record: | http://purl.flvc.org/ucf/fd/CFH2000097 | |
| Restrictions on Access: | public | |
| Host Institution: | UCF |
