You are here

PROPOSED BIOMEDICAL APPLICATIONS OF ZIRCONIUM-BASED METAL-ORGANIC FRAMEWORKS AS DRUG DELIVERY SYSTEMS

Download pdf | Full Screen View

Date Issued:
2019
Abstract/Description:
Metal-organic frameworks (MOFs) are a class of highly crystalline nanoporous materials that self-assemble from inorganic metal oxide clusters and multitopic organic linkers. MOFs can be altered in terms of the types of metals and structures of organic linkers used, allowing for a high degree of customization and manipulation of the synergistic chemical or physical properties that arise from the precise coordination of their molecular components, including exceptionally large surface area and pore size. Zirconium-based MOFs, called UiOs in honor of their conception at the University of Oslo, also show remarkable chemical stability in both acidic and basic environments, making them excellent candidates for biomedical applications as drug delivery systems, where they can either function as molecular cargo ships, with drugs packed into their pores, or as controlled release systems, in which drug molecules are directly attached to their ligands for precise delivery. The objective of this work is to prepare water-stable MOFs whose linkers are decorated with functional groups that have potential compatibility in drug delivery systems and to explore the efficacy of certain synthesis conditions in terms of the crystallinity of the MOF product. Thus, we hope to establish a basis for the ligation of anticancer drugs and fluorescent tags to MOFs for their controlled release at a specified location within the body. These targeted release mechanisms represent new therapeutic possibilities in terms of cancer treatment as their specificity would mitigate damage to healthy tissues, thereby addressing one of the greatest weakness of present treatment options.
Title: PROPOSED BIOMEDICAL APPLICATIONS OF ZIRCONIUM-BASED METAL-ORGANIC FRAMEWORKS AS DRUG DELIVERY SYSTEMS.
11 views
5 downloads
Name(s): Perry-Mills, Ariel Margaret, Author
Uribe-Romo, Fernando, Committee Chair
Borgon, Robert, Committee Member
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2019
Publisher: University of Central Florida
Language(s): English
Abstract/Description: Metal-organic frameworks (MOFs) are a class of highly crystalline nanoporous materials that self-assemble from inorganic metal oxide clusters and multitopic organic linkers. MOFs can be altered in terms of the types of metals and structures of organic linkers used, allowing for a high degree of customization and manipulation of the synergistic chemical or physical properties that arise from the precise coordination of their molecular components, including exceptionally large surface area and pore size. Zirconium-based MOFs, called UiOs in honor of their conception at the University of Oslo, also show remarkable chemical stability in both acidic and basic environments, making them excellent candidates for biomedical applications as drug delivery systems, where they can either function as molecular cargo ships, with drugs packed into their pores, or as controlled release systems, in which drug molecules are directly attached to their ligands for precise delivery. The objective of this work is to prepare water-stable MOFs whose linkers are decorated with functional groups that have potential compatibility in drug delivery systems and to explore the efficacy of certain synthesis conditions in terms of the crystallinity of the MOF product. Thus, we hope to establish a basis for the ligation of anticancer drugs and fluorescent tags to MOFs for their controlled release at a specified location within the body. These targeted release mechanisms represent new therapeutic possibilities in terms of cancer treatment as their specificity would mitigate damage to healthy tissues, thereby addressing one of the greatest weakness of present treatment options.
Identifier: CFH2000531 (IID), ucf:45634 (fedora)
Note(s): 2019-05-01
B.S.
College of Medicine, Burnett School of Biomedical Sciences
Bachelors
This record was generated from author submitted information.
Subject(s): metal-organic frameworks
drug delivery system
MOFs
nanomedicine
UiO-66
UiO-68
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFH2000531
Restrictions on Access: public
Host Institution: UCF

In Collections