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LITERATURE REVIEW ON THE USE OF NUCLEIC ACID-BASED LOGIC GATES FOR THE DETECTION OF HUMAN DISEASES

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Date Issued:
2017
Abstract/Description:
Conventional methods for diagnosis of human disease are, at times, limited in different regards including time requirement, either experimental or data processing, sensitivity, and selectivity. It is then that a Point of Care Criteria, which considers the true utility and usefulness of the device, is employed to propose new diagnostic devices capable of overcoming the aforementioned shortcomings of conventional tools. Nucleic acid, characterized for its predictable base-pairing nature, is considered to be a highly-selective, yet greatly modifiable device. Its behavior is then described through Boolean Logic, where "true" or "false" outputs are mathematically described as "1" and "0", respectively. This mathematical approach is then referred to as Logic Gates, where outputs can be predicted based on satisfied environmental conditions. The mechanisms, capable of exhibiting Logic Gate behavior, are described.
Title: LITERATURE REVIEW ON THE USE OF NUCLEIC ACID-BASED LOGIC GATES FOR THE DETECTION OF HUMAN DISEASES.
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Name(s): Blanco Martinez, Enrique J, Author
Kolpashchikov, Dmitry, Committee Chair
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2017
Publisher: University of Central Florida
Language(s): English
Abstract/Description: Conventional methods for diagnosis of human disease are, at times, limited in different regards including time requirement, either experimental or data processing, sensitivity, and selectivity. It is then that a Point of Care Criteria, which considers the true utility and usefulness of the device, is employed to propose new diagnostic devices capable of overcoming the aforementioned shortcomings of conventional tools. Nucleic acid, characterized for its predictable base-pairing nature, is considered to be a highly-selective, yet greatly modifiable device. Its behavior is then described through Boolean Logic, where "true" or "false" outputs are mathematically described as "1" and "0", respectively. This mathematical approach is then referred to as Logic Gates, where outputs can be predicted based on satisfied environmental conditions. The mechanisms, capable of exhibiting Logic Gate behavior, are described.
Identifier: CFH2000256 (IID), ucf:46006 (fedora)
Note(s): 2017-12-01
B.S.
College of Sciences, Chemistry
Bachelors
This record was generated from author submitted information.
Subject(s): Biosensors
DNA
Logic Gate
Toe-Hold
Review
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFH2000256
Restrictions on Access: public
Host Institution: UCF

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