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EFFECTIVENESS OF PROBIOTICS IN PREVENTING ANTIBIOTIC ASSOCIATED DIARRHEA AND CLOSTRIDIUM DIFFICILE IN LONG TERM CARE

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Date Issued:
2010
Abstract/Description:
Purpose: Antibiotic associated diarrhea (AAD) and clostridium-difficile diarrhea (CDAD) are the most common forms of infectious diarrhea in long term care facilities. The purpose of this study is to determine the effectiveness of probiotics in preventing AAD and CDAD in the long term care geriatric population, and to identify interventions which can be used to improve clinical practice. Methods: This was a retrospective cohort study. The study population consisted of residents of a LTC facility who were sixty-five years of age and older who were administered antibiotic therapies with or without co-administration of probiotics. A data collection instrument which was created for this study was piloted prior to its use in the study. Chi-square test of independence and CochranÂÂ's Q were the proposed statistical analysis procedures used to determine relationships between variables. Results: Eighty-three residents received antibiotics. In the forty-four residents who were administered probiotic with antibiotic, five cases of diarrhea were reported. In the thirty-nine residents who received antibiotics without probiotics, two cases of diarrhea were reported. Analysis with chi-square test of independence comparing the relationship between antibiotic administration with and without probiotic and AAD prevention, was (X²(1) =1.041, p=0.308). No cases of CDAD were found in the group who received antibiotic (s) and a probiotic. One case of CDAD was found in the group which received no probiotic with the antibiotic. Analysis with chi-square test of independence comparing the relationship between antibiotic administration with or without probiotic and CDAD prevention was (X²(1) =1.142, p=0.285). Discussion/Implication: The results of this study showed no statistically significant evidence to support the effectiveness of probiotic use in the prevention of AAD or CDAD in this population. The incidence of AAD was higher in the group who received a probiotic at the time of antibiotic administration.
Title: EFFECTIVENESS OF PROBIOTICS IN PREVENTING ANTIBIOTIC ASSOCIATED DIARRHEA AND CLOSTRIDIUM DIFFICILE IN LONG TERM CARE.
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Name(s): Edwards-Marshall, Marva, Author
Wink, Dianne, Committee Chair
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2010
Publisher: University of Central Florida
Language(s): English
Abstract/Description: Purpose: Antibiotic associated diarrhea (AAD) and clostridium-difficile diarrhea (CDAD) are the most common forms of infectious diarrhea in long term care facilities. The purpose of this study is to determine the effectiveness of probiotics in preventing AAD and CDAD in the long term care geriatric population, and to identify interventions which can be used to improve clinical practice. Methods: This was a retrospective cohort study. The study population consisted of residents of a LTC facility who were sixty-five years of age and older who were administered antibiotic therapies with or without co-administration of probiotics. A data collection instrument which was created for this study was piloted prior to its use in the study. Chi-square test of independence and CochranÂÂ's Q were the proposed statistical analysis procedures used to determine relationships between variables. Results: Eighty-three residents received antibiotics. In the forty-four residents who were administered probiotic with antibiotic, five cases of diarrhea were reported. In the thirty-nine residents who received antibiotics without probiotics, two cases of diarrhea were reported. Analysis with chi-square test of independence comparing the relationship between antibiotic administration with and without probiotic and AAD prevention, was (X²(1) =1.041, p=0.308). No cases of CDAD were found in the group who received antibiotic (s) and a probiotic. One case of CDAD was found in the group which received no probiotic with the antibiotic. Analysis with chi-square test of independence comparing the relationship between antibiotic administration with or without probiotic and CDAD prevention was (X²(1) =1.142, p=0.285). Discussion/Implication: The results of this study showed no statistically significant evidence to support the effectiveness of probiotic use in the prevention of AAD or CDAD in this population. The incidence of AAD was higher in the group who received a probiotic at the time of antibiotic administration.
Identifier: CFE0003281 (IID), ucf:48532 (fedora)
Note(s): 2010-08-01
D.N.P.
Health and Public Affairs, School of Nursing
Masters
This record was generated from author submitted information.
Subject(s): Probiotics
long term care
antibiotic associated diarrhea
clostridium difficile
geriatrics.
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFE0003281
Restrictions on Access: public
Host Institution: UCF

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