You are here

Phosphatidic Acid Increases Lean Body Tissue and Strength In Resistance Trained Men

Download pdf | Full Screen View

Date Issued:
2012
Abstract/Description:
ABSTRACTPhosphatidic Acid (PA) is a natural phospholipid compound derived from lecithin which is commonly found in egg yolk, grains, fish, soybeans, peanuts and yeast. It has been suggested that PA is involved in several intracellular processes associated with muscle hypertrophy. Specifically, PA has been reported to activate protein synthesis through the mammalian target of rapamycin (mTOR) signaling pathway and thereby may enhance the anabolic effects of resistance training. To our knowledge, no one has examined the effect of PA supplementation in humans while undergoing a progressive resistance training program. To examine the effect of PA supplementation on lean soft tissue mass (LM) and strength after 8 weeks of resistance training.Fourteen resistance-trained men (mean (&)#177; SD; age 22.7 (&)#177; 3.3 yrs; height: 1.78 (&)#177; 0.10m; weight: 89.3 (&)#177; 16.3 kg) volunteered to participate in this randomized, double-blind, placebo-controlled, repeated measures study. The participants were assigned to a PA group (750mg/day; Mediator(&)#174;, ChemiNutra, MN, n=7) or placebo group (PL; rice flower; n=7), delivered in capsule form that was identical in size, shape and color. Participants were tested for 1RM strength in the bench press (BP) and squat (SQ) exercise. LM was measured using dual-energy X-ray absorptiometry. After base line testing, the participants began supplementing PA or PLfor 8 weeks during a progressive resistance training program intended for muscular hypertrophy. Data was analyzed using magnitude-based inferences on mean changes for BP, SQ and LM. Furthermore, the magnitudes of the inter-relationships between changes in total training volume and LM were interpreted using Pearson correlation coefficients, which had uncertainty (90% confidence limits) of approximately +0.25.In the PA group, the relationship between changes in training volume and LM was large(r=0.69, +0.27; 90%CL), however, in the PL group the relationship was small (r=0.21, +0.44; 90%CL). PA supplementation was determined to be likely beneficial at improving SQ and LM over PL by 26% and 64%, respectively. The strong relationship between changes in total training volume and LM in the PA group suggest that greater training volume most likely lead to the greater changes in LM, however, no such relationship was found with PL group. For the BP data, the PA group resulted in a 42% greater increase in strength over PL, although the effect was considered unclear. While more research is needed to elucidate mechanism of action; the current findings suggest that in experienced resistance trained men supplementing 750mg PA per day for 8 weeks may likely benefit greater changes in muscle mass and strength compared with resistance training only. ?
Title: Phosphatidic Acid Increases Lean Body Tissue and Strength In Resistance Trained Men.
12 views
5 downloads
Name(s): Williams, David, Author
Hoffman, Jay, Committee Chair
Fragala, Maren, Committee Member
Stout, Jeffrey, Committee Member
, Committee Member
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2012
Publisher: University of Central Florida
Language(s): English
Abstract/Description: ABSTRACTPhosphatidic Acid (PA) is a natural phospholipid compound derived from lecithin which is commonly found in egg yolk, grains, fish, soybeans, peanuts and yeast. It has been suggested that PA is involved in several intracellular processes associated with muscle hypertrophy. Specifically, PA has been reported to activate protein synthesis through the mammalian target of rapamycin (mTOR) signaling pathway and thereby may enhance the anabolic effects of resistance training. To our knowledge, no one has examined the effect of PA supplementation in humans while undergoing a progressive resistance training program. To examine the effect of PA supplementation on lean soft tissue mass (LM) and strength after 8 weeks of resistance training.Fourteen resistance-trained men (mean (&)#177; SD; age 22.7 (&)#177; 3.3 yrs; height: 1.78 (&)#177; 0.10m; weight: 89.3 (&)#177; 16.3 kg) volunteered to participate in this randomized, double-blind, placebo-controlled, repeated measures study. The participants were assigned to a PA group (750mg/day; Mediator(&)#174;, ChemiNutra, MN, n=7) or placebo group (PL; rice flower; n=7), delivered in capsule form that was identical in size, shape and color. Participants were tested for 1RM strength in the bench press (BP) and squat (SQ) exercise. LM was measured using dual-energy X-ray absorptiometry. After base line testing, the participants began supplementing PA or PLfor 8 weeks during a progressive resistance training program intended for muscular hypertrophy. Data was analyzed using magnitude-based inferences on mean changes for BP, SQ and LM. Furthermore, the magnitudes of the inter-relationships between changes in total training volume and LM were interpreted using Pearson correlation coefficients, which had uncertainty (90% confidence limits) of approximately +0.25.In the PA group, the relationship between changes in training volume and LM was large(r=0.69, +0.27; 90%CL), however, in the PL group the relationship was small (r=0.21, +0.44; 90%CL). PA supplementation was determined to be likely beneficial at improving SQ and LM over PL by 26% and 64%, respectively. The strong relationship between changes in total training volume and LM in the PA group suggest that greater training volume most likely lead to the greater changes in LM, however, no such relationship was found with PL group. For the BP data, the PA group resulted in a 42% greater increase in strength over PL, although the effect was considered unclear. While more research is needed to elucidate mechanism of action; the current findings suggest that in experienced resistance trained men supplementing 750mg PA per day for 8 weeks may likely benefit greater changes in muscle mass and strength compared with resistance training only. ?
Identifier: CFE0004641 (IID), ucf:49897 (fedora)
Note(s): 2012-05-01
M.S.
Education, Child, Family and Community Sciences
Masters
This record was generated from author submitted information.
Subject(s): Phosphatidic Acid -- PA -- increases -- lean tissue mass -- strength -- resistance -- trained -- men -- mTOR
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFE0004641
Restrictions on Access: public 2012-11-15
Host Institution: UCF

In Collections