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Role of brain derived neurotrophic factor (BDNF) in stimulating strength improvements induced by short-term resistance training

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Date Issued:
2018
Abstract/Description:
Strength adaptations from short-term resistance training are thought to be related primarily to neurological adaptations. Considering brain-derived neurotrophic factor (BDNF) role in the nervous system, it is possible that BDNF has a role in these adaptations. Fourteen untrained males were randomized into either a resistance training (RT; n =8) or control (CON; n=6) group. Motor unit (MU) recruitment at 50% and 80% of each participant's maximal voluntary isometric contraction (MVIC), muscle cross sectional area (CSA) and thickness (MT), as well as one-repetition maximum (1RM) of the squat (SQT), leg press (LP), and leg extension (LE) were performed before (PRE) and after (POST) the training period. Following the MU assessment, the recruitment threshold (RT; % MVIC) and mean firing rate (MFR; pulse per second [pps]) of each MU were determined. Linear regression was used to quantify the slope (pps/% MVIC) and y-intercept (pps) of the MFR versus RT relationship for each participant and time point. Participants completed an acute resistance exercise bout at PRE and POST consisting of 3 sets of 8 (-) 10 repetitions with 90 seconds of rest between each set of SQT, LP, and LE. Blood samples were obtained following a 4-hour fast before (BL), immediately-(IP), and one-(1H) hour post resistance exercise. RT subjects performed the same resistance exercise protocol at PRE twice a week for 3-weeks. CON subjects were instructed to not perform any resistance exercise. Area under the curve (AUC) analysis was determined by the trapezoidal method. Pearson product-moment correlations were used to examine selected bivariate relationships. The ?BDNF AUC was significantly correlated to the relative 80% ?y-intercept (r=-0.626, p=0.030), and trended to be correlated to the relative 80% ?slope (r=0.551, p=0.063). Our results indicate that ? in plasma BDNF concentrations appear to be related to ?'s MU recruitment at high intensities (80% of MVIC) of exercise.
Title: Role of brain derived neurotrophic factor (BDNF) in stimulating strength improvements induced by short-term resistance training.
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Name(s): Church, David, Author
Hoffman, Jay, Committee Chair
Stout, Jeffrey, Committee Member
Fukuda, David, Committee Member
Stock, Matt, Committee Member
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2018
Publisher: University of Central Florida
Language(s): English
Abstract/Description: Strength adaptations from short-term resistance training are thought to be related primarily to neurological adaptations. Considering brain-derived neurotrophic factor (BDNF) role in the nervous system, it is possible that BDNF has a role in these adaptations. Fourteen untrained males were randomized into either a resistance training (RT; n =8) or control (CON; n=6) group. Motor unit (MU) recruitment at 50% and 80% of each participant's maximal voluntary isometric contraction (MVIC), muscle cross sectional area (CSA) and thickness (MT), as well as one-repetition maximum (1RM) of the squat (SQT), leg press (LP), and leg extension (LE) were performed before (PRE) and after (POST) the training period. Following the MU assessment, the recruitment threshold (RT; % MVIC) and mean firing rate (MFR; pulse per second [pps]) of each MU were determined. Linear regression was used to quantify the slope (pps/% MVIC) and y-intercept (pps) of the MFR versus RT relationship for each participant and time point. Participants completed an acute resistance exercise bout at PRE and POST consisting of 3 sets of 8 (-) 10 repetitions with 90 seconds of rest between each set of SQT, LP, and LE. Blood samples were obtained following a 4-hour fast before (BL), immediately-(IP), and one-(1H) hour post resistance exercise. RT subjects performed the same resistance exercise protocol at PRE twice a week for 3-weeks. CON subjects were instructed to not perform any resistance exercise. Area under the curve (AUC) analysis was determined by the trapezoidal method. Pearson product-moment correlations were used to examine selected bivariate relationships. The ?BDNF AUC was significantly correlated to the relative 80% ?y-intercept (r=-0.626, p=0.030), and trended to be correlated to the relative 80% ?slope (r=0.551, p=0.063). Our results indicate that ? in plasma BDNF concentrations appear to be related to ?'s MU recruitment at high intensities (80% of MVIC) of exercise.
Identifier: CFE0006988 (IID), ucf:51665 (fedora)
Note(s): 2018-05-01
Ph.D.
Education and Human Performance, Dean's Office EDUC
Doctoral
This record was generated from author submitted information.
Subject(s): BDNF -- Motor Units -- Electromyography -- Resistance Training
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFE0006988
Restrictions on Access: campus 2019-05-15
Host Institution: UCF

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