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Transient Multi-scale Computational Fluid Dynamics (CFD) Model for Thrombus Tracking in an Assit Device Vascular Bed

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Date Issued:
2013
Abstract/Description:
Heart failure occurs when the heart is not capable to pump blood at a sufficient rate to meet the demands of the body. Depending on the health of the heart, doctors may recommend a heart transplant, but finding a suitable donor is often a long duration process and the patient might be at an advance condition or the patient is not adequate for a heart transplant. In such cases Ventricular assist devices (VAD) are implemented. The purpose of a VAD is to aid the heart to pump the correct amount of blood, by doing so it relives the load that is put on the heart while giving the patient a chance for recovery. This study focuses on observing the hemodynamic effects of implementing a left ventricular assist device (LVAD) along the aortic arch and main arteries. Thrombi creation and transportation is other subject included in the study, due to the fact that thrombi can obstruct blood flow to critical arteries, manly carotid and vertebral. Occlusion of these can lead to a stroke with devastating effects on the neurocognitive functions and even death.A multi-scale CFD analysis a patient specific geometry model is used as well as a lumped system which provides the correct conditions in order to simulate the whole cardiovascular system. The main goal of the study is to understand the difference in flow behavior created by the unsteady pulsatile boundary conditions. The model described in this work has a total cardiac output of 7.0 Liters/ minute, this for a healthy heart. Two cardiac output splits are used to simulate heart failure conditions. The first split consists of 5 Liters/minute flowing through the LVAD cannula and 2 Liters/minute via the aortic root. The second scenario is when heartivfailure is critical, meaning that zero flow is being output by the left ventricle, thus a split of 7 Liter/minute trough the LVAD cannula and 0 Liters/minute traveling through the aortic root. A statistical analysis for the thrombi motion throughout the patient aortic arch was performed in order to quantify the influence that pulsatile flow has on the particles being track. Spherical particles of 2mm, 4mm and 5mm were released and accounted in the statistical analysis for each of the two split configurations. The study focuses on particles that escaped on the outlet boundaries of the upper arteries (Right Carotid, Left Carotid, and Vertebral). Results exhibit the statistical comparison of means for each particle diameter as well as for the overall probability for the steady and unsteady flow condition.
Title: Transient Multi-scale Computational Fluid Dynamics (CFD) Model for Thrombus Tracking in an Assit Device Vascular Bed.
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Name(s): Osorio, Ruben, Author
Kassab, Alain, Committee Chair
Divo, Eduardo, Committee CoChair
Ilie, Marcel, Committee Member
, Committee Member
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2013
Publisher: University of Central Florida
Language(s): English
Abstract/Description: Heart failure occurs when the heart is not capable to pump blood at a sufficient rate to meet the demands of the body. Depending on the health of the heart, doctors may recommend a heart transplant, but finding a suitable donor is often a long duration process and the patient might be at an advance condition or the patient is not adequate for a heart transplant. In such cases Ventricular assist devices (VAD) are implemented. The purpose of a VAD is to aid the heart to pump the correct amount of blood, by doing so it relives the load that is put on the heart while giving the patient a chance for recovery. This study focuses on observing the hemodynamic effects of implementing a left ventricular assist device (LVAD) along the aortic arch and main arteries. Thrombi creation and transportation is other subject included in the study, due to the fact that thrombi can obstruct blood flow to critical arteries, manly carotid and vertebral. Occlusion of these can lead to a stroke with devastating effects on the neurocognitive functions and even death.A multi-scale CFD analysis a patient specific geometry model is used as well as a lumped system which provides the correct conditions in order to simulate the whole cardiovascular system. The main goal of the study is to understand the difference in flow behavior created by the unsteady pulsatile boundary conditions. The model described in this work has a total cardiac output of 7.0 Liters/ minute, this for a healthy heart. Two cardiac output splits are used to simulate heart failure conditions. The first split consists of 5 Liters/minute flowing through the LVAD cannula and 2 Liters/minute via the aortic root. The second scenario is when heartivfailure is critical, meaning that zero flow is being output by the left ventricle, thus a split of 7 Liter/minute trough the LVAD cannula and 0 Liters/minute traveling through the aortic root. A statistical analysis for the thrombi motion throughout the patient aortic arch was performed in order to quantify the influence that pulsatile flow has on the particles being track. Spherical particles of 2mm, 4mm and 5mm were released and accounted in the statistical analysis for each of the two split configurations. The study focuses on particles that escaped on the outlet boundaries of the upper arteries (Right Carotid, Left Carotid, and Vertebral). Results exhibit the statistical comparison of means for each particle diameter as well as for the overall probability for the steady and unsteady flow condition.
Identifier: CFE0004905 (IID), ucf:49633 (fedora)
Note(s): 2013-08-01
M.S.M.E.
Engineering and Computer Science, Mechanical and Aerospace Engineering
Masters
This record was generated from author submitted information.
Subject(s): Assit Device -- Time Dependent Multi-Scale model -- Thrombus Tracking
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFE0004905
Restrictions on Access: public 2013-08-15
Host Institution: UCF

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