You are here

UCF Digital Collections ยป ETD Collection

Computational Fluid Dynamics Study of Thromboembolism as a Function of Shunt Size and Placement in the Hybrid Norwood Palliative Treatment of Hypoplastic Left Heart Syndrome

Download pdf | Full Screen View

Date Issued:
2017
Abstract/Description:
The Hybrid Norwood procedure has emerged as a promising alternative palliative first stage treatment for infants with Hypoplastic Left Heart Syndrome (HLHS). The procedure is done to provide necessary blood flow to the pulmonary and systemic regions of the body. The procedure can affect hemodynamic conditions to be pro-thrombotic, and thrombus particles can form and release from the vessel walls and enter the flow. Assuming these particles are formed and released from the shunt surface, a Computational Fluid Dynamics (CFD) model can be used to mimic the patient's vasculature geometry and predict the occurrence of embolization to the carotid or coronary arteries, as well as the other major arteries surrounding the heart. This study used a time dependent, multi-scale CFD analysis on patient-specific geometry to determine the statistical probability of thrombus particles exiting each major artery. The geometries explored were of a nominal and patient specific nature. Cases of 90% and 0% stenosis at the aortic arch were analyzed, including shunt diameters of 3mm, 3.5mm, and 4mm. Three different placements of the shunt were explored as well. The intent of this study was to suggest best methods of surgical planning in the Hybrid Norwood procedure by providing supporting data for optimal stroke and myocardial infarction prevention.
Title: Computational Fluid Dynamics Study of Thromboembolism as a Function of Shunt Size and Placement in the Hybrid Norwood Palliative Treatment of Hypoplastic Left Heart Syndrome.
36 views
15 downloads
Name(s): Seligson, John, Author
Kassab, Alain, Committee Chair
DeCampli, William, Committee Member
Mansy, Hansen, Committee Member
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2017
Publisher: University of Central Florida
Language(s): English
Abstract/Description: The Hybrid Norwood procedure has emerged as a promising alternative palliative first stage treatment for infants with Hypoplastic Left Heart Syndrome (HLHS). The procedure is done to provide necessary blood flow to the pulmonary and systemic regions of the body. The procedure can affect hemodynamic conditions to be pro-thrombotic, and thrombus particles can form and release from the vessel walls and enter the flow. Assuming these particles are formed and released from the shunt surface, a Computational Fluid Dynamics (CFD) model can be used to mimic the patient's vasculature geometry and predict the occurrence of embolization to the carotid or coronary arteries, as well as the other major arteries surrounding the heart. This study used a time dependent, multi-scale CFD analysis on patient-specific geometry to determine the statistical probability of thrombus particles exiting each major artery. The geometries explored were of a nominal and patient specific nature. Cases of 90% and 0% stenosis at the aortic arch were analyzed, including shunt diameters of 3mm, 3.5mm, and 4mm. Three different placements of the shunt were explored as well. The intent of this study was to suggest best methods of surgical planning in the Hybrid Norwood procedure by providing supporting data for optimal stroke and myocardial infarction prevention.
Identifier: CFE0006655 (IID), ucf:51232 (fedora)
Note(s): 2017-05-01
M.S.M.E.
Engineering and Computer Science, Mechanical and Aerospace Engineering
Masters
This record was generated from author submitted information.
Subject(s): Hybrid Norwood -- Hypoplastic Left Heart Syndrome -- Computational Fluid Dynamics -- Thrombosis -- Embolism -- Stenosis -- Patient Specific -- Lagrangian Tracking -- Reverse Blalock-Taussig shunt
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFE0006655
Restrictions on Access: public 2017-05-15
Host Institution: UCF

In Collections