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Engineering Noble-metal Nanostructures for Biosensing Applications

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Date Issued:
2019
Abstract/Description:
The ability to engineer noble-metal nanostructures (NMNSs) in a controllable manner and to understand the structure-dependent properties greatly boost our knowledge in rational design of biosensing technologies. In particular, as a type of highly efficient peroxidase mimics, NMNSs hold promising potential to break through the bottleneck of conventional enzyme-based in vitro diagnostics.During the time of my Ph.D. study, I have successfully: 1) directed a two-step method involving seed-mediated growth and chemical etching for the synthesis of Ru nanoframes (RuNFs) with face-centered cubic crystal phase and enhanced catalytic activities; 2) demonstrated, for the first time, the inherent peroxidase-like activity of RuNFs as a type of efficient peroxidase mimics, opening up possibilities for their bioapplications; 3) developed an enzyme-free signal amplification technique for ultrasensitive colorimetric assay of disease biomarkers by using Pd-Ir nanooctahedra encapsulated gold vesicles as labels; 4) prepared polyvinylpyrrolidone (PVP)-capped Pt nanocubes with superior peroxidase-like catalytic activity and record-high specific catalytic activity; 5) developed a facile colorimetric method for the detection of Ag(I) ions with picomolar sensitivity by using the PVP-capped Pt nanocubes as the probes; 6) developed a non-enzyme cascade amplification strategy for colorimetric assay of disease biomarkers by taking advantage of the interaction between the Ag(I) ions and PVP-capped Pt nanocubes; and 7) established a highly sensitive colorimetric lateral flow assay platform by using Au@Pt core-shell nanoparticles as the labels that possess both plasmonic and catalytic properties.
Title: Engineering Noble-metal Nanostructures for Biosensing Applications.
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Name(s): Ye, Haihang, Author
Xia, Xiaohu, Committee Chair
Kuebler, Stephen, Committee Member
Chen, Gang, Committee Member
Beazley, Melanie, Committee Member
Feng, Xiaofeng, Committee Member
University of Central Florida, Degree Grantor
Type of Resource: text
Date Issued: 2019
Publisher: University of Central Florida
Language(s): English
Abstract/Description: The ability to engineer noble-metal nanostructures (NMNSs) in a controllable manner and to understand the structure-dependent properties greatly boost our knowledge in rational design of biosensing technologies. In particular, as a type of highly efficient peroxidase mimics, NMNSs hold promising potential to break through the bottleneck of conventional enzyme-based in vitro diagnostics.During the time of my Ph.D. study, I have successfully: 1) directed a two-step method involving seed-mediated growth and chemical etching for the synthesis of Ru nanoframes (RuNFs) with face-centered cubic crystal phase and enhanced catalytic activities; 2) demonstrated, for the first time, the inherent peroxidase-like activity of RuNFs as a type of efficient peroxidase mimics, opening up possibilities for their bioapplications; 3) developed an enzyme-free signal amplification technique for ultrasensitive colorimetric assay of disease biomarkers by using Pd-Ir nanooctahedra encapsulated gold vesicles as labels; 4) prepared polyvinylpyrrolidone (PVP)-capped Pt nanocubes with superior peroxidase-like catalytic activity and record-high specific catalytic activity; 5) developed a facile colorimetric method for the detection of Ag(I) ions with picomolar sensitivity by using the PVP-capped Pt nanocubes as the probes; 6) developed a non-enzyme cascade amplification strategy for colorimetric assay of disease biomarkers by taking advantage of the interaction between the Ag(I) ions and PVP-capped Pt nanocubes; and 7) established a highly sensitive colorimetric lateral flow assay platform by using Au@Pt core-shell nanoparticles as the labels that possess both plasmonic and catalytic properties.
Identifier: CFE0007559 (IID), ucf:52626 (fedora)
Note(s): 2019-05-01
Ph.D.
Sciences, Chemistry
Doctoral
This record was generated from author submitted information.
Subject(s): Noble metal ? nanostructures ? peroxidase mimics ? in vitro diagnostics ? biosensing technique ? colorimetric detection
Persistent Link to This Record: http://purl.flvc.org/ucf/fd/CFE0007559
Restrictions on Access: public 2019-05-15
Host Institution: UCF

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