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How many are out there? A novel approach for open and closed systems
Title
How many are out there? A novel approach for open and closed systems.
Creator
Rehman, Zia, Kincaid, John, Wiegand, Rudolf, Finch, Craig, Uddin, Nizam, University of Central Florida
Abstract / Description
We propose a ratio estimator to determine population estimates using capture-recapture sampling. It's different than traditional approaches in the following ways:(1)Ordering of recaptures: Currently data sets do not take into account the "ordering" of the recaptures, although this crucial information is available to them at no cost. (2)Dependence of trials and cluster sampling: Our model explicitly considers trials to be dependent and improves existing literature which assumes independence. ...
Show moreWe propose a ratio estimator to determine population estimates using capture-recapture sampling. It's different than traditional approaches in the following ways:(1)Ordering of recaptures: Currently data sets do not take into account the "ordering" of the recaptures, although this crucial information is available to them at no cost. (2)Dependence of trials and cluster sampling: Our model explicitly considers trials to be dependent and improves existing literature which assumes independence. (3)Rate of convergence: The percentage sampled has an inverse relationship with population size, for a chosen degree of accuracy. (4)Asymptotic Attainment of Minimum Variance (Open Systems: (=population variance).(5)Full use of data and model applicability (6)Non-parametric (7)Heterogeneity: When units being sampled are hard to identify. (8)Open and closed systems: Simpler results are presented separately for closed systems.(9)Robustness to assumptions in open systems
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Date Issued
2014
Identifier
CFE0005403, ucf:50411
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0005403
Modeling Transport and Protein Adsorption in Microfluidic Systems
Title
Modeling Transport and Protein Adsorption in Microfluidic Systems.
Creator
Finch, Craig, Hickman, James, Kincaid, John, Lin, Kuo-Chi, Behal, Aman, Cho, Hyoung, University of Central Florida
Abstract / Description
This work describes theoretical advances in the modeling and simulation of microfluidic systems and demonstrates the practical application of those techniques. A new multi-scale model of the adsorption of hard spheres was formulated to bridge the gap between simulations of discrete particles and continuum fluid dynamics. A whispering gallery mode (WGM) biosensor was constructed and used to measure the kinetics of adsorption for two types of proteins on four different surfaces. Computational...
Show moreThis work describes theoretical advances in the modeling and simulation of microfluidic systems and demonstrates the practical application of those techniques. A new multi-scale model of the adsorption of hard spheres was formulated to bridge the gap between simulations of discrete particles and continuum fluid dynamics. A whispering gallery mode (WGM) biosensor was constructed and used to measure the kinetics of adsorption for two types of proteins on four different surfaces. Computational fluid dynamics was used to analyze the transport of proteins in the flow cell of the biosensor. Kinetic models of protein adsorption that take transport limitations into account were fitted to the experimental data and used to draw conclusions about the mechanisms of adsorption. Transport simulations were then applied to the practical problem of optimizing the design of a microfluidic bioreactor to enable (")plugs(") of fluid to flow from one chamber to the next with minimal dispersion. Experiments were used to validate the transport simulations. The combination of quantitative modeling and simulation and experiments led to results that could not have been achieved using either approach by itself. Simulation tools that accurately predict transport and protein adsorption will enable the rational design of microfluidic devices for biomedical applications.
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Date Issued
2011
Identifier
CFE0004474, ucf:49313
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0004474