Current Search:   Scott, Rosanna (x)

View All Items

  • CSV Spreadsheet
(1 - 2 of 2)
Cognitive and vascular risk factors for depression: Testing an integrated theoretical framework
Title
Cognitive and vascular risk factors for depression: Testing an integrated theoretical framework.
Creator
Scott, Rosanna, Paulson, Daniel, Rapport, Mark, Dvorak, Robert, Dangiolo, Mariana, University of Central Florida
Abstract / Description
Objective: Theoretical models that have guided the study of later-life depression include the vascular depression hypothesis, depression-executive dysfunction syndrome, and the CaR-FA-X model. Evidence suggests these can be integrated into a single developmental model of disordered mood (and its associated overgeneral memory feature) in later-life to delineate a mechanism of the vascular depression effect and identify modifiable intervention targets.Methods: In older adults, four serial...
Show moreObjective: Theoretical models that have guided the study of later-life depression include the vascular depression hypothesis, depression-executive dysfunction syndrome, and the CaR-FA-X model. Evidence suggests these can be integrated into a single developmental model of disordered mood (and its associated overgeneral memory feature) in later-life to delineate a mechanism of the vascular depression effect and identify modifiable intervention targets.Methods: In older adults, four serial mediation models evaluated the relationships between (1) vascular burden and depressive symptoms via executive control and rumination, and (2) vascular burden and autobiographical memory specificity (AMS) via executive control and rumination. In younger adults, four simple mediation models were conducted to compare results to older adults, including models assessing the relationships between (1) executive control and depressive symptoms via rumination, and (2) executive control and AMS via rumination. Bias-corrected bootstrapping was employed throughout.Results: Older adult n=56; younger adult n=63. Older adult serial mediation models demonstrated significant individual relationships between a working memory measure and depressive symptoms, as well as between rumination and depressive symptoms. The vascular depression effect neared significance. No other direct or indirect effects were supported. In younger adults, rumination was significantly associated with depressive symptoms; all other hypothesized relationships were not significant.Conclusions: Model 1, evaluating the impact of vascular burden on depressive symptoms in older adults via working memory and rumination, respectively, was the most effective in integrating vascular depression, DED, and CaR-FA-X. However, there was not support for a vascular depression mechanism. Null results in this sample could be attributable to inadequate power or measurement error. Clinically, results promote interventions that target older adults presenting with depression, executive dysfunction, or rumination, independently or combined.
Show less
Date Issued
2019
Identifier
CFE0007860, ucf:52759
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0007860
Cerebrovascular Burden and Depression: Examining a Process Model of Geriatric Developmental Psychopathology
Title
Cerebrovascular Burden and Depression: Examining a Process Model of Geriatric Developmental Psychopathology.
Creator
Scott, Rosanna, Paulson, Daniel, Cassisi, Jeffrey, Jentsch, Florian, University of Central Florida
Abstract / Description
Depression is the second leading cause of disability worldwide, and is associated with substantial functional impairment and poor health implications in older adults. These adverse outcomes are exacerbated in older adults who exhibit comorbid depression and cerebrovascular burden (CVB). Given that the population of older adults is projected to double by year 2050, a process model of the development of depression in later-life and a subsequent clear delineation of the relationship between CVB...
Show moreDepression is the second leading cause of disability worldwide, and is associated with substantial functional impairment and poor health implications in older adults. These adverse outcomes are exacerbated in older adults who exhibit comorbid depression and cerebrovascular burden (CVB). Given that the population of older adults is projected to double by year 2050, a process model of the development of depression in later-life and a subsequent clear delineation of the relationship between CVB and depression is paramount. One explanation of this process of disease development is the vascular depression theory, however alternative hypotheses have not been exhaustively falsified and the literature consists of methodological barriers that produce potentially unreliable results. The goals of this thesis are (1) to examine the interrelationship between CVB and depressive symptomatology from mid-life to later-life, and (2) to assess a potential genetic modifier of the CVB/depressive symptomatology relationship. Participants were drawn from the Wisconsin Longitudinal Study, which represents the 1957 graduating class from Wisconsin high schools. Data was drawn from three waves (1993, 2004, and 2011), spanning 18 years. Study 1 utilized a dual-change model to evaluate the relationship between CVB and depressive symptomatology from mid-life to later-life. Results indicated that depressive symptomatology at both follow-up waves was predicted by earlier depressive symptomatology. Prior CVB significantly predicted future depressive symptomatology in both 2004 and 2011. Depressive symptomatology in 2004 significantly predicted CVB in 2011. Thus, CVB significantly predicted future depressive symptomatology even after accounting for prior depressive symptomatology. Study 2 utilized a repeated-measures ANOVA and a moderated path structural model to evaluate the moderating effect of ApoE carriage on the relationship between CVB and depressive symptomatology. Results indicated that ApoE carriage has no significant main effect on depressive symptomatology, nor is it a significant moderator of the relationship between CVB and depressive symptomatology. Overall findings strongly support the vascular depression theory, and do not implicate ApoE carriage in the manifestation of depressive symptomatology. Future research should longitudinally evaluate the relationship between CVB and depressive symptomatology across a greater number of defined time points and with a more diverse sample. Lastly, future research should continue to identify genetic risk factors that influence the development of detrimental disease processes.
Show less
Date Issued
2016
Identifier
CFE0006178, ucf:51121
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0006178