Current Search: Sweeney, Michael J. (x)
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Title
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Immunological studies of the host parasite relationship of Dirofilaria immitis in domestic canines.
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Creator
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Qualls, Douglas Felton, Sweeney, Michael J., Natural Sciences
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Abstract / Description
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Florida Technological University College of Natural Sciences Thesis; Canine immunoglobulins of the IgG group were shown to be intimately associated with the cuticle of circulating non-infection Dirofilaria immitis microfilaria. The significance of these immunoglobulins in blocking a complete immune response in the definitive host is discussed. Immunodiffusion, immunoelectrophoresis and fluorescent inhibition techniques are described and their applicability to the study of host-parasite...
Show moreFlorida Technological University College of Natural Sciences Thesis; Canine immunoglobulins of the IgG group were shown to be intimately associated with the cuticle of circulating non-infection Dirofilaria immitis microfilaria. The significance of these immunoglobulins in blocking a complete immune response in the definitive host is discussed. Immunodiffusion, immunoelectrophoresis and fluorescent inhibition techniques are described and their applicability to the study of host-parasite relationships are evaluated. A rapid reproducible method for the production of specifically labeled anti-D. immitis microfilaria globulins is presented.
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Date Issued
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1975
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Identifier
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CFR0003520, ucf:52993
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Format
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Document (PDF)
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PURL
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http://purl.flvc.org/ucf/fd/CFR0003520
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Title
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Antibodies to milk antigens in human coronary heart disease.
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Creator
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Spinos, Efstathios, Sweeney, Michael J., Natural Sciences
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Abstract / Description
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Florida Technological University College of Natural Sciences Thesis; Milk protein has been implicated as a factor in the development of atherosclerosis. Significantly higher titers of antibodies (P
Show moreFlorida Technological University College of Natural Sciences Thesis; Milk protein has been implicated as a factor in the development of atherosclerosis. Significantly higher titers of antibodies (P < 0.0002) toward milk antigens were observed in patients suffering from coronary heart disease as compared to age matched controls. These hemagglutination titers were not sex related but may have been related to age. Specificity of the antigen-antibody reaction was demonstrated by a hemagglutination inhibition test. The complement fixation test was evaluated and was less sensitive than the tanned hemaggIutination test. Treatment with 2-mercapto-ethanol resulted in reduced hemagglutination titers, indicating that significant antibody activity may be due to IgM. A special application of the Combs test detected specific antibodies on the surface of tanned and coated RBC which did not otherwise produce detectable agglutination.
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Date Issued
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1977
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Identifier
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CFR0003521, ucf:52985
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Format
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Document (PDF)
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PURL
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http://purl.flvc.org/ucf/fd/CFR0003521
