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A DIRECT COMPENSATOR PROFILE OPTIMIZATION APPROACH FOR INTENSITY MODULATED RADIATION TREATMENT PLANNING
Title
A DIRECT COMPENSATOR PROFILE OPTIMIZATION APPROACH FOR INTENSITY MODULATED RADIATION TREATMENT PLANNING.
Creator
Erhart, Kevin, Divo, Eduardo, University of Central Florida
Abstract / Description
Radiation therapy accounts for treatment of over one million cancer patients each year in the United States alone, and its use will continue to grow rapidly in the coming years. Recently, many important advancements have been developed that greatly improve the outcomes and effectiveness of this treatment technique, the most notable being Intensity Modulated Radiation Therapy (IMRT). IMRT is a sophisticated treatment technique where the radiation dose is conformed to the tumor volume, thereby...
Show moreRadiation therapy accounts for treatment of over one million cancer patients each year in the United States alone, and its use will continue to grow rapidly in the coming years. Recently, many important advancements have been developed that greatly improve the outcomes and effectiveness of this treatment technique, the most notable being Intensity Modulated Radiation Therapy (IMRT). IMRT is a sophisticated treatment technique where the radiation dose is conformed to the tumor volume, thereby sparing nearby healthy tissue from excessive radiation dose. While IMRT is a valuable tool in the planning of radiation treatments, it is not without its difficulties. This research has created, developed, and tested an innovative approach to IMRT treatment planning, coined Direct Compensator Profile Optimization (DCPO), which is shown to eliminate many of the difficulties typically associated with IMRT planning and delivery using solid compensator based treatment. The major innovation of this technique is that it is a direct delivery parameter optimization approach which has adopted a parameterized surface representation using Non-Uniform Rational B-Splines (NURBs) to replace the conventional beamlet weight optimization approach. This new approach brings with it three key advantages: 1) a reduced number of parameters to optimize, reducing the difficulty of numerical optimization; 2) the ability to ensure complete equivalence of planned and actual manufactured compensators; and 3) direct inclusion of delivery device effects during planning with no performance penalties, eliminating the degrading fluence-to-delivery parameter conversion process. Detailed research into the affects of the DCPO approach on IMRT planning has been completed and a thorough analysis of the developments is provided herein. This research includes a complete description of the DCPO surface representation scheme, inverse planning process, as well as quantification of the manufacturing constraint control procedure. Results are presented which demonstrate the performance and innovation offered by this new approach and show that the resulting compensator shapes can be manufactured to nearly 100 percent of the designed shape.
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Date Issued
2009
Identifier
CFE0002800, ucf:48099
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0002800
Online Path Planning and Control Solution for a Coordinated Attack of Multiple Unmanned Aerial Vehicles in a Dynamic Environment
Title
Online Path Planning and Control Solution for a Coordinated Attack of Multiple Unmanned Aerial Vehicles in a Dynamic Environment.
Creator
Vega-Nevarez, Juan, Qu, Zhihua, Haralambous, Michael, Xu, Yunjun, University of Central Florida
Abstract / Description
The role of the unmanned aerial vehicle (UAV) has significantly expanded in the military sector during the last decades mainly due to their cost effectiveness and their ability to eliminate the human life risk. Current UAV technology supports a variety of missions and extensive research and development is being performed to further expand its capabilities. One particular field of interest is the area of the low cost expendable UAV since its small price tag makes it an attractive solution for...
Show moreThe role of the unmanned aerial vehicle (UAV) has significantly expanded in the military sector during the last decades mainly due to their cost effectiveness and their ability to eliminate the human life risk. Current UAV technology supports a variety of missions and extensive research and development is being performed to further expand its capabilities. One particular field of interest is the area of the low cost expendable UAV since its small price tag makes it an attractive solution for target suppression. A swarm of these low cost UAVs can be utilized as guided munitions or kamikaze UAVs to attack multiple targets simultaneously. The focus of this thesis is the development of a cooperative online path planning algorithm that coordinates the trajectories of these UAVs to achieve a simultaneous arrival to their dynamic targets. A nonlinear autopilot design based on the dynamic inversion technique is also presented which stabilizes the dynamics of the UAV in its entire operating envelope. A nonlinear high fidelity six degrees of freedom model of a fixed wing aircraft was developed as well that acted as the main test platform to verify the performance of the presented algorithms
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Date Issued
2012
Identifier
CFE0004613, ucf:49925
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0004613