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Fabrication of Polyelectrolyte Nanoparticles Through Hydrophobic Interaction
Title
Fabrication of Polyelectrolyte Nanoparticles Through Hydrophobic Interaction.
Creator
Catarata, Ruginn Porce, Zhai, Lei, Kang, Ellen, Huo, Qun, University of Central Florida
Abstract / Description
Anticancer drugs like gemcitabine (GEM) are used to treat cancers such as, pancreatic ductal adenocarcinoma (PDAC). However, the use of free gemcitabine yields challenges including cytotoxicity to healthy cells and poor circulation time. By encapsulating GEM in nanoparticles these challenges can be overcome. In this study poly(acrylic acid) (PAA)-GEM nanoparticles are fabricated by coupling GEM onto PAA. The particle formation is driven by the hydrophobic interaction of GEM, which collects in...
Show moreAnticancer drugs like gemcitabine (GEM) are used to treat cancers such as, pancreatic ductal adenocarcinoma (PDAC). However, the use of free gemcitabine yields challenges including cytotoxicity to healthy cells and poor circulation time. By encapsulating GEM in nanoparticles these challenges can be overcome. In this study poly(acrylic acid) (PAA)-GEM nanoparticles are fabricated by coupling GEM onto PAA. The particle formation is driven by the hydrophobic interaction of GEM, which collects in the core of the nanoparticle, forming a PAA shell. The nanoparticles were optimized by studying the PAA/GEM ratio and pH during fabrication. Characteristics of the nanoparticles including size, morphology and surface charge were investigated using dynamic light scattering (DLS), transmission electron microscopy (TEM) and zeta potential measurements. Conditions such as ionic stability and pH stability were optimized to achieve high drug loading efficiency. Cell uptake and cytotoxicity studies were used to determine the efficiency of the nanoparticles as drug delivery vehicle.
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Date Issued
2019
Identifier
CFE0007791, ucf:52364
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0007791