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- Title
- NON-INVASIVE POSITIVE PRESSURE VENTILATION (NPPV): ITS USES, COMPLICATIONS, & IMPLICATIONS WITHIN NURSING PRACTICE IN ACUTE CARE SETTINGS.
- Creator
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Marano, Alexis, Sole, Mary, University of Central Florida
- Abstract / Description
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The use of noninvasive positive pressure ventilation (NPPV) in acute care settings has drastically increased within the past 20 years. Research has indicated that NPPV is equally as effective as traditional mechanical ventilation(MV) in treating acute exacerbations of chronic pulmonary obstructive disease (COPD) and cardiogenic pulmonary edema. Furthermore, the risk of complication from NPPV is much lower than MV, in terms of ventilator-associated pneumonia and sepsis. It is imperative for...
Show moreThe use of noninvasive positive pressure ventilation (NPPV) in acute care settings has drastically increased within the past 20 years. Research has indicated that NPPV is equally as effective as traditional mechanical ventilation(MV) in treating acute exacerbations of chronic pulmonary obstructive disease (COPD) and cardiogenic pulmonary edema. Furthermore, the risk of complication from NPPV is much lower than MV, in terms of ventilator-associated pneumonia and sepsis. It is imperative for the nurse to understand the various indications, interfaces, and potential complications associated with NPPV use. In addition to treating acute exacerbations of COPD and cardiogenic pulmonary edema, NPPV has been used for prevention of reintubation, palliative care, and status asthmaticus. Furthermore, NPPV could be delivered through various interfaces, such as nasal, facial, and helmet. Each of these interfaces could eventually cause complications for the patient, such as skin ulceration and sepsis. However, there is limited amount of research available discussing the role of the nurse in caring for the patient with NPPV. There are no standardized guidelines established to assist the nurse in this care, in terms of interface selection, prevention of complications, and staffing patterns. Several recommendations are presented at the end of this thesis to guide future nursing research, education, and clinical practice, such as exploring the role of oral care and education for NPPV patients.
Show less - Date Issued
- 2012
- Identifier
- CFH0004276, ucf:44937
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFH0004276
- Title
- The effects of dynamic versus isometric postactivation potentiation on collegiate female rowers.
- Creator
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Harat, Idan, Fukuda, David, Stout, Jeffrey, Wells, Adam, University of Central Florida
- Abstract / Description
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Post-activation potentiation (PAP) has been shown to improve acute power-based performance, and the potential to enhance rowing performance. To examine PAP effects with rowing performance, 40 collegiate female rowers performed isometric potentiating (ISO), dynamic potentiating (DYN) and typical control (CON) warm-up protocols, after which they completed a three-minute all-out test (3MT) to evaluate their total distance, peak power, mean power, critical power, anaerobic working capacity (W')...
Show morePost-activation potentiation (PAP) has been shown to improve acute power-based performance, and the potential to enhance rowing performance. To examine PAP effects with rowing performance, 40 collegiate female rowers performed isometric potentiating (ISO), dynamic potentiating (DYN) and typical control (CON) warm-up protocols, after which they completed a three-minute all-out test (3MT) to evaluate their total distance, peak power, mean power, critical power, anaerobic working capacity (W') and stroke rate. Fifteen-second splits for distance and mean power were also analyzed. The PAP protocols were performed on a rowing ergometer, in a movement pattern that simulated rowing. ISO consisted of 5 (&)#215; 5-second static muscle actions with the ergometer handle rendered immovable with a nylon boat-strap, while DYN consisted of 2 (&)#215; 10-second all-out rowing bouts, separated by a 2-minute rest interval. A two-way (condition by experience level) interaction was found for distance, mean power and W' with significant differences (DYN (>) CON; 5.6 m, 5.9W and 1561.6 J) for more experienced rowers ((>)3.75 years; n=19) and no differences for less experienced rowers (n=18). A main effect for stroke rate was found with DYN(>)CON (1 s/min). Split analysis of mean power output revealed a two-way (condition by 15s split) interaction independent from experience level. Mean power in DYN was significantly greater than CON and ISO in the 15-30, 30-45, 45-60 and 60-75 second intervals. These results suggest that dynamic PAP may be beneficial for experienced rowers and that these strategies might benefit a greater power output over shorter distances regardless of experience. Future studies should investigate potential benefits of this protocol over a full race distance and identify the difference between experienced and less experienced rowers.
Show less - Date Issued
- 2019
- Identifier
- CFE0007465, ucf:52665
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0007465
- Title
- THE ANTI-HIV-1 ACTIVITY OF HUMAN SEMINAL PLASMA.
- Creator
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Martellini, Julie, Cole, Alexander, University of Central Florida
- Abstract / Description
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Human immunodeficiency virus (HIV) has become a global pandemic over the past few decades, with new infections and related deaths in the millions each year. There is no cure in sight for HIV-1 infection, and there has been little progress in developing an efficacious vaccine. Heterosexual transmission of HIV-1 remains the principal mode of transmission throughout the world and thus measures, such as topical vaginal microbicides, to prevent infection of the female reproductive tract are...
Show moreHuman immunodeficiency virus (HIV) has become a global pandemic over the past few decades, with new infections and related deaths in the millions each year. There is no cure in sight for HIV-1 infection, and there has been little progress in developing an efficacious vaccine. Heterosexual transmission of HIV-1 remains the principal mode of transmission throughout the world and thus measures, such as topical vaginal microbicides, to prevent infection of the female reproductive tract are actively being explored. Recent trials of topical vaginal microbicides have shown that their interaction with the mucosal surfaces of the female reproductive tract as well as semen can hinder microbicide effectiveness against HIV-1 infection. Therefore, understanding the role these fluids play in HIV transmission would be critical towards developing effective antiviral prophylaxes. A recent study from our group demonstrated that human cervicovaginal secretions contained numerous cationic antimicrobial peptides and proteins, which collectively inhibited HIV-1 infection of target cells and tissues. To ascertain if human seminal plasma (SP), the main vector responsible for transmitting HIV-1, exhibited antiviral activity we utilized several anti-HIV assays in the presence or absence of minimally manipulated SP. The majority of the intrinsic anti-HIV-1 activity of SP resided in the cationic polypeptide fraction. Antiviral assays utilizing luciferase reporter cells and lymphocytic cells revealed the ability of whole SP to prevent HIV-1 infection, even when SP was diluted 3200-fold. Subsequent fractionation by continuous flow acid-urea (AU)-PAGE and antiviral testing revealed that cationic polypeptides within SP were responsible for the majority of anti-HIV-1 activity. A proteomic approach was utilized to resolve and identify 52 individual cationic polypeptides that contribute to the aggregate anti-HIV-1 activity of SP. One peptide fragment of semenogelin I, termed SG-1, was purified from SP by a multi-step chromatographic approach, protein sequenced, and determined to exhibit anti-HIV-1 activity against HIV-1. Anti-HIV-1 activity was transient, as whole SP incubated for prolonged time intervals exhibited a proportional decrease in anti-HIV-1 activity that was directly attributed to the degradation of semenogelin I peptides. Collectively, these results indicate that the cationic polypeptide fraction of SP is active against HIV-1, and that semenogelin-derived peptides contribute to the intrinsic anti-HIV-1 activity of SP. Conversely, naturally occurring peptidic fragments from the SP-derived prostatic acid phosphatase (PAP) have been reported to form amyloid fibrils called "SEVI" capable of enhancing HIV-1 infection in vitro. In order to understand the biological consequence of this proviral effect, we extended these studies in the presence of human SP. PAP-derived peptides were agitated to form SEVI and incubated in the presence or absence of SP. While PAP-derived peptides and SEVI alone were proviral, the presence of 1% SP ablated their proviral activity in several different anti-HIV-1 assays. The anti-HIV-1 activity of SP was concentration dependent and was reduced following filtration. Supraphysiological concentrations of PAP peptides and SEVI incubated with diluted SP were degraded within hours, with SP exhibiting proteolytic activity at dilutions as high as 1:200. Sub-physiological concentrations of two prominent proteases of SP, prostate-specific antigen (PSA) and matriptase, could degrade physiological and supraphysiological concentrations of PAP peptides and SEVI. While human SP is a complex biological fluid, containing both antiviral and proviral factors, our results suggest that PAP peptides and SEVI may be subject to naturally occurring proteolytic components capable of reducing their proviral activity. Our studies demonstrate the overall antiviral activity of human SP, but there is still a critical need for effective topical vaginal microbicides that can prevent HIV-1 transmission. The synthetic human retrocyclins are cyclic antimicrobial peptides that are remarkably active against HIV-1, and are being developed as topical vaginal microbicides. Herein, we assessed whether the putative proviral SEVI was able to adversely affect the anti-HIV-1 activity of the retrocyclin analog RC-101. While SEVI alone enhanced viral infection, this effect was completely negated in the presence of RC-101. Retrocyclins such as RC-101 are inhibitors of HIV-1 entry, by preventing gp41-mediated viral fusion. Interestingly, using an HIV-1 reverse transcriptase (RT) specific assay, we also determined that RC-101 directly inhibited the activity of RT in a dose dependent manner, suggesting a secondary mechanism of viral inhibition. Our group has determined that RC-101 induces only a modest level of resistance in HIV, which may be due in part to RC-101's dual mechanisms of viral inhibition.
Show less - Date Issued
- 2011
- Identifier
- CFE0003583, ucf:48916
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0003583
