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(1 - 11 of 11)
- Title
- FACTORS THAT AFFECT ADHERENCE WITH LONG-TERM CONTROLLER MEDICATIONS USED TO MANAGE ASTHMA IN CHILDREN.
- Creator
-
Bowks, Brittany, Draves , Krisann, University of Central Florida
- Abstract / Description
-
Problem: Asthma affects one out of every ten children in the United States. It is recommended that children with persistent asthma take long-term controller (LTC) medications to achieve control. However, adherence varies, and many children do not take their LTC medication at all. The average cost for hospitalization of a child with asthma is $8,406. Asthma in children also contributes to school absenteeism and a decrease in quality of life. Objective: A literature review was performed to...
Show moreProblem: Asthma affects one out of every ten children in the United States. It is recommended that children with persistent asthma take long-term controller (LTC) medications to achieve control. However, adherence varies, and many children do not take their LTC medication at all. The average cost for hospitalization of a child with asthma is $8,406. Asthma in children also contributes to school absenteeism and a decrease in quality of life. Objective: A literature review was performed to examine factors that affect adherence to LTC medications used to control asthma in children. Method: A literature review was performed using the CINAHL, ERIC, Medline, Psych Info, and Academic Search Premier databases. Keywords included asthma AND child* OR pediatric* AND adherence OR compliance AND corticosteroid* OR "leukotriene modifier*" OR "mast cell stabilizer*" OR "monoclonal antibod*" OR "long-acting beta agonist.*" After applying exclusion criteria 35 articles were included in this review. Results: A variety of factors that affect adherence were identified. Internal factors included age, sex, and race/ethnicity. External factors included socioeconomic status, environment, health perception, lack of motivation, parental education, disease/medication beliefs, family dynamics and planning, responsibility, severity, and exacerbations. Interventional factors included caregiver-family communication, asthma knowledge, specialty care, white coat adherence, number of prescriptions, asthma action plans, medication regimens, and technology. Conclusion: It is recommended that healthcare providers use a four-step process during inpatient and outpatient asthma visits. The steps include assess and educate, collaborate, problem-solve, and follow-up. Collectively, this method can help healthcare providers overcome many of the barriers that were identified.
Show less - Date Issued
- 2015
- Identifier
- CFH0004809, ucf:45438
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFH0004809
- Title
- Adherence Practices of Caucasian Women With Hypertension Residing in Rural Florida: An Exploratory Study.
- Creator
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Hopple, Jeanne, Bushy, Angeline, Sole, Mary, Covelli, Maureen, Oetjen, Dawn, University of Central Florida
- Abstract / Description
-
Hypertension, or high blood pressure, is a major risk factor for heart disease and stroke. Elevated blood pressure is often a silent process affecting multiple organ systems. Risk for heart disease is associated with poorly treated or unrecognized hypertension that is more common among women than men. Non-adherence to prescribed treatment regimens has been identified as a major reason for inadequate hypertension management. This exploratory descriptive qualitative study using narrative...
Show moreHypertension, or high blood pressure, is a major risk factor for heart disease and stroke. Elevated blood pressure is often a silent process affecting multiple organ systems. Risk for heart disease is associated with poorly treated or unrecognized hypertension that is more common among women than men. Non-adherence to prescribed treatment regimens has been identified as a major reason for inadequate hypertension management. This exploratory descriptive qualitative study using narrative inquiry investigated adherence practices among Caucasian women with diagnoses of hypertension from a rural area of Florida. The purpose of this study was to gain an understanding from women who had been diagnosed with hypertension about the challenges of living with and managing this chronic condition in their daily lives. Participants included Caucasian women (n = 11) recruited from a Federally Qualified Rural Health Center in Florida. Semi-structured interviews were used to collect data. Content analysis procedures were used to analyze the interviews. Emergent themes included: work stress affecting health and leading to high blood pressure; silent (")sneaky, gradual(") onset of mild to moderate symptoms leading to high blood pressure; and strong influence of family members with high blood pressure and related complications that instilled fear in participants to adhere to their prescribed treatment plan in some, or in others to non-adherence. Social support from friends and coworkers was a repeated theme supporting adherence. Minor themes associated with non-adherence included fear of potential side effects of medications, challenges of daily living caring for family, fatigue from high blood pressure and medications affecting daily work, poor food choices due to finances and availability of high sodium and fatty foods at work and home, stress and time demands affecting ability to exercise to control high blood pressure, and focus on family forgetting self-needs. Limitations of the study included a small convenience sample with findings that may not be applicable to a population of hypertensive women from different rural settings. Future nursing studies in similar populations may contribute to improved adherence practices, leading to reduced complications from poorly controlled hypertension.
Show less - Date Issued
- 2011
- Identifier
- CFE0004120, ucf:49100
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0004120
- Title
- Predictors of Immunosuppressant Adherence in Long-Term Renal Transplant Recipients.
- Creator
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Galura, Sandra, Sole, Mary, Allred, Kelly, Byers, Jacqueline, Lawrence, Shawn, University of Central Florida
- Abstract / Description
-
To sustain the health and viability of renal transplants, adherence to immunosuppressant therapy (IST) medications is critical. Studies continue to identify decreased adherence rates as time from transplant increases (Chisholm-Burns, Kwong, Mulloy (&) Spivey, 2008; Chisholm, Lance, Mulloy, 2005; Chisholm, Mulloy, (&) DiPiro, 2005; Nivens (&) Thomas, 2009). While previous research has explored the effect of variables known to influence IST adherence in adult renal transplant recipients,...
Show moreTo sustain the health and viability of renal transplants, adherence to immunosuppressant therapy (IST) medications is critical. Studies continue to identify decreased adherence rates as time from transplant increases (Chisholm-Burns, Kwong, Mulloy (&) Spivey, 2008; Chisholm, Lance, Mulloy, 2005; Chisholm, Mulloy, (&) DiPiro, 2005; Nivens (&) Thomas, 2009). While previous research has explored the effect of variables known to influence IST adherence in adult renal transplant recipients, limited studies have explored these variables in a population of renal transplant recipients with longer time posttransplant intervals. The purpose of this study was to examine demographic variables, time posttransplant, immunosuppressive agents, health beliefs, social support, and symptom experience and test their relationship to adherence in a population of long-term renal transplant recipients.A cross-sectional correlational design was used to collect data from a convenience sample of 98 adult renal transplant recipients who were three or more years from transplant. Participants completed five instruments: 1) demographic survey, 2) the Beliefs About Medicines Questionnaire (BMQ), 3) the Medical Outcomes Study (MOS) Modified Social Support Survey (&)#172;(&)#172;(&)#172;(&)#172;(&)#172;(&)#172;(&)#172;(&)#172;(&)#172;(&)#172;(&)#172;(&)#172;(&)#172;(&)#172;(&)#172; (MSSS), 4) the Basel Assessment of Adherence with Immunosuppressive Medication Scales (BAASIS), and 5) the Modified Transplant Symptom Occurrence and Symptom Distress Scale-59R (MTSOSD-59R). A composite adherence score (CAS) consisting of a self-report measure of adherence (BAASIS), nontherapeutic serum drug assay, and collateral report of adherence as provided by two transplant clinic professionals was used to determine final adherence group classification (adherent/nonadherent). Analysis of the relationship between all independent variables and adherence was conducted using Spearman's rho correlation coefficient. Mean scores for medication complexity, health beliefs, social support, and symptom experience were compared between age, gender, and time posttransplant groups using independent-samples t tests. A logistic regression prediction of probability was conducted to determine which of the variables that demonstrated a significant relationship to adherence were most predictive of adherence.Of the total sample population (N = 98), 39.8% (n = 39) were classified as adherent and 60.2% (n = 59) were nonadherent. Results demonstrated no significant relationship between age (continuous variable), time posttransplant, immunosuppressant medications (measured by a medication complexity index), health beliefs, symptom experience, and adherence. Weak, but significant relationships between age groups (r = -.213, p=.035), tangible social support (r = .215, p =.017), emotional informational social support (r = .274, p = .003), positive social interaction support (r = .199, p = .025), total overall social support (r = .274, p =.003) and composite adherence group classification were found. Older participants ((>) 55 yrs) were significantly less adherent than younger ((<) 54 yrs) participants. Mean scores for emotional / informational (EMI), positive social interaction (POS), and total social support (MSSS) were significantly lower in nonadherent participants. Regression results indicated the overall model of two predictors (age grouped [(<) 54 yrs; (>) 55 yrs] and EMI social support subscale) was statistically reliable in distinguishing between adherent and nonadherent participants (-2 Log Likelihood 116.244; Goodness-of-Fit x2 (2) = 13.664, p = .001), correctly classifying 69.1% of the cases. Findings from this study contribute to the body of research exploring predictors of immunosuppressant adherence in long-term renal transplant recipients. Data suggest both younger age ((<) 55) and categories of social support predict adherence in long-term renal transplant recipients. Healthcare providers caring for renal transplant recipients long-term should consider annually assessing older participants for adherence as well as for changes in social networks.
Show less - Date Issued
- 2012
- Identifier
- CFE0004203, ucf:49013
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0004203
- Title
- THE RELATIONSHIP BETWEEN PATIENT EDUCATION AND ADHERENCE TO ANTIBIOTIC REGIMENS: EXPLORING PROFILES OF ADHERENT GROUPS.
- Creator
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McSweeney, Morgan, Borgon, Robert, University of Central Florida
- Abstract / Description
-
Objective: Currently, there does not exist a cohesive and predictive set of criteria that can be used to identify patients that are at risk of being non-adherent to antibiotic regimens. In this study, we sought to answer the question of whether patients' knowledge of the scientific background of antibiotic resistance is related to their likelihood to adhere to antibiotic regimens. Additionally, we explored other facets of the profiles of adherent and non-adherent subjects. Methods: All...
Show moreObjective: Currently, there does not exist a cohesive and predictive set of criteria that can be used to identify patients that are at risk of being non-adherent to antibiotic regimens. In this study, we sought to answer the question of whether patients' knowledge of the scientific background of antibiotic resistance is related to their likelihood to adhere to antibiotic regimens. Additionally, we explored other facets of the profiles of adherent and non-adherent subjects. Methods: All responses were collected via questionnaire. Subjects were split into two groups (adherent and non-adherent) based upon four patient-behavior questions. These two groups of subjects were compared in a variety of ways to test for significant differences in categories such as science knowledge, age, and self-reported understanding of the problem of antibiotic resistance. Results: It was determined that the adherent group of subjects had significantly higher science scores (mean=5.46, n=384) than the non-adherent subjects (mean=4.99, n=460); t(842)= -2.73, p=0.0064. Subjects majoring in STEM were more likely to be adherent than biology or non-STEM majors. There were no differences in adherence or science scores across age groups. About 26% of subjects had not previously heard of the problem of antibiotic resistance. Discussion: Increasing patient education on the topic of antibiotic resistance could increase patient adherence, which could in turn lead to a reduction in the rate at which bacteria develop resistance. Initiatives to educate patients and health care professionals have the potential to increase understanding and improve rates of adherence.
Show less - Date Issued
- 2015
- Identifier
- CFH0004784, ucf:45351
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFH0004784
- Title
- CLOPIDOGREL PROVISION FOR INDIGENT PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION.
- Creator
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Price, Sita, Sole, Mary Lou, University of Central Florida
- Abstract / Description
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The Joint Commission in a joint effort with the Centers of Medicare and Medicaid Services (CMS) has established certain "core measures" by which hospital performance is measured. One of these is the measure for patients with ST-elevation myocardial infarction (STEMI) recommending percutaneous coronary intervention within 90 minutes of presentation to the Emergency Department in institutions that are able to provide this service. This recommendation does not take into account the long-term use...
Show moreThe Joint Commission in a joint effort with the Centers of Medicare and Medicaid Services (CMS) has established certain "core measures" by which hospital performance is measured. One of these is the measure for patients with ST-elevation myocardial infarction (STEMI) recommending percutaneous coronary intervention within 90 minutes of presentation to the Emergency Department in institutions that are able to provide this service. This recommendation does not take into account the long-term use of clopidogrel that is recommended by the American College of Cardiology and American Heart Association for patients that are treated with coronary stents. The purpose of this study was to evaluate outcomes of providing a short course of clopidogrel versus a prescription alone for clopidogrel to uninsured patients experiencing STEMI who were treated with a bare metal stent. After conducting a cost-benefit analysis, a policy was approved that provided uninsured STEMI patients with clopidogrel at discharge rather than a prescription. A social worker evaluated patients to determine if they met criteria and arranged for medication delivery to the patient's bedside. A retrospective chart review for all patients who presented to the Emergency Department during two different time frames (before and after policy implementation) was conducted to evaluate if providing clopidogrel decreased readmissions. Data were collected on over a 15-month period of time before and after the clopidogrel policy implementation to allow for evaluation of 90-day readmissions with repeat STEMI. Data were analyzed using chi-square cross tabulation and T-test for independent samples. A total of 201 charts were reviewed: 100 from the pre-intervention group and 101 from the post-intervention group. Demographic characteristics of age, gender and insurance status were not statistically different between groups. The mean age for the control group was 59.1 (+ 13.8) years and 58.9 (+ 13.6) years for the intervention group. Twenty percent of the patients were uninsured. Five uninsured patients were readmitted with STEMI prior to the intervention compared to two patients in the intervention group (p = .191). The admissions for the pre-intervention patients occurred in the first 30 days after discharge compared to 31-60 days in the post-intervention group. All of the patients who were readmitted were assessed to be noncompliant with treatment. Additionally, a transition to increased use of bare metal stents in STEMI patients from 23.1% pre-intervention to 67.4% post-intervention was noted (p < .001). Although no differences were found in readmission rates, fewer readmissions for STEMI were noted after the intervention. The small number of patients who were readmitted with STEMI likely accounted for this finding, and additional monitoring of readmission rates is warranted. Despite provision of the clopidogrel, adherence remains an issue and needs to be addressed. During the intervention, physicians were encouraged to consider the financial and social resources of individual STEMI patients presenting to the Emergency Department to help identify patients that would be less likely to adhere to antiplatelet therapy. In those believed to be at high risk for non-adherence, primarily due to inability to purchase the relatively expensive medication clopidogrel, many physicians chose to insert bare metal stents rather than drug-eluting stents to take advantage of the shorter course of clopidogrel required post procedure. Provision of a 30-day course of clopidogrel and aspirin was a major part of this effort to decrease recurrent myocardial infarction in this at-risk population. A few patients eligible for the clopidogrel were not provided the medication if they were admitted to a nursing unit where staff members were not familiar with the policy; revisions to the policy to ensure medication is provided to all eligible patients will be made. Providing clopidogrel to patients who experience STEMI may improve adherence and thereby decrease readmissions as a result of repeat STEMI due to subacute thrombus formation. Patients who experience STEMI continue to be vulnerable after STEMI. Programs that provide medication to patients should be expanded within this facility and to other hospital systems to encompass all patients who are treated for STEMI. Multi-disciplinary collaboration is necessary in developing and implementing a program that will address care for this.
Show less - Date Issued
- 2011
- Identifier
- CFE0003940, ucf:48685
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0003940
- Title
- HEALTH INSURANCE STATUS AND DIABETES MANAGEMENT PRACTICES AMONG BLACK ADULTS IN THE U.S.
- Creator
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Rosier, Luderve, Wells, Brittny, University of Central Florida
- Abstract / Description
-
The purpose of this study was to investigate the relationship between health insurance status and diabetes management (in terms of medication adherence and physical activity levels) in Black adults based on socioeconomic factors. Data were harvested from the Sample Adult Questionnaires of the National Health Interview Survey (NHIS) between the years of 2010 and 2016. The survey questions that were collected included information about the participants' income, education level, insurance status...
Show moreThe purpose of this study was to investigate the relationship between health insurance status and diabetes management (in terms of medication adherence and physical activity levels) in Black adults based on socioeconomic factors. Data were harvested from the Sample Adult Questionnaires of the National Health Interview Survey (NHIS) between the years of 2010 and 2016. The survey questions that were collected included information about the participants' income, education level, insurance status, diabetes diagnosis, medication therapy and physical activity levels. This study employed the most recent version of the Statistical Package for Social Sciences (SPSS) software. The association between diabetes management and socioeconomic factors were analyzed using chi-square analysis. It was hypothesized that Black adults who were uninsured, lower income, and less-educated would report lower adherence to medication and lower physical activity participation when compared to their insured, higher income, and higher-educated counterparts. However, there was no statistically significant relationship between health insurance status and diabetes management in people of different socioeconomic status. Too few people met the weekly recommendations for moderate exercise thus chi-square outcomes for physical activity were invalid. This study will be beneficial for future research as it has provided more generalizable information on this topic due to the use of a national dataset. This study also highlighted the importance of adequate physical activity interventions for this population and can be used for further research on Black adults with diabetes.
Show less - Date Issued
- 2018
- Identifier
- CFH2000303, ucf:45751
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFH2000303
- Title
- THE EFFECT OF TEXT MESSAGING ALERTS UPON TESTICULAR SELF-EXAMINATION (TSE) ADHERENCE.
- Creator
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Soler, Lisa, Rovito, Michael, University of Central Florida
- Abstract / Description
-
Based on Kim Witte's proven Extended Parallel Process Model, a mobile communication system was developed in which men were sent reminders about their health. This study focused on reminding men about testicular self-examination (TSE), a proactive behavior used to detect testicular cancer, through the use of text messaging. A cohort of 75 men were recruited for this study and placed into one of four groups. All participants were provided with information concerning TSE and told to perform the...
Show moreBased on Kim Witte's proven Extended Parallel Process Model, a mobile communication system was developed in which men were sent reminders about their health. This study focused on reminding men about testicular self-examination (TSE), a proactive behavior used to detect testicular cancer, through the use of text messaging. A cohort of 75 men were recruited for this study and placed into one of four groups. All participants were provided with information concerning TSE and told to perform the exam monthly; two of the four groups were sent reminders via text message while the other two groups were told once about the behavior. An original 30-item survey was used to measure intention. Proper data analysis could not be performed due to an attrition rate of 71%. Nonetheless, a significant relationship was observed between pre- and post-test adherence as reported by the participants. In addition, the measurement tool was assessed and determined to be useful in measuring intention to perform TSE. Internal consistency measures were reported as 0.672 and 0.626, both of which would have been higher with a larger sample size. While further research and analysis is recommended, this study has laid a foundation for a way to communicate with young men about their health.
Show less - Date Issued
- 2012
- Identifier
- CFH0004320, ucf:45058
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFH0004320
- Title
- THE EFFECT OF BRIEF TRAINING IN MOTIVATIONAL INTERVIEWING ON CLIENT OUTCOMES AND TRAINEE SKILL DEVELOPMENT.
- Creator
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Young, Tabitha, Hagedorn, Bryce, University of Central Florida
- Abstract / Description
-
Motivational Interviewing (MI) is an evidence-based practice that focuses on working through client ambivalence and increasing clientsÂÂ' motivation to change. The purposes of this study were to investigate the effect that a unique student-based training in MI had on counselor traineesÂÂ' ability to perform MI, and on client outcomes. This training program consisted of one initial four-hour training session, two hours of follow-up supervision, and...
Show moreMotivational Interviewing (MI) is an evidence-based practice that focuses on working through client ambivalence and increasing clientsÂÂ' motivation to change. The purposes of this study were to investigate the effect that a unique student-based training in MI had on counselor traineesÂÂ' ability to perform MI, and on client outcomes. This training program consisted of one initial four-hour training session, two hours of follow-up supervision, and formal feedback via MITI 3.0 scores. Counselor-trainee skill was assessed via the MI Knowledge Questionnaire, the Helping Responses questionnaire, and the Motivational Interviewing Treatment Integrity code 3.0. In addition, the following instruments were used to assess client outcomes ; attendance via observation assessments, the Session Summary, the Outcome Questionnaire-45.2, and the Client Satisfaction Questionnaire. The sample consisted of 43 graduate-level counselor trainees in their first or second semesters of practicum and 81 adult clients being seen in a university-based graduate student-training counseling clinic. Participants were purposefully assigned to either a treatment or control group. The counselor trainees in the treatment group received the unique training program, follow-up supervision, and feedback whereas the participants in the control group received a four-hour orientation to the student-training counseling clinic. There were four primary hypotheses proposed for analysis within this study (a) How does a brief training in Motivational Interviewing given to counselor trainees affect their ability to accurately perform MI?, (b) How does a brief training in Motivational Interviewing given to counselor trainees affect client functioning?, (c) How does a brief training in Motivational Interviewing given to counselor trainees affect client adherence?, and (d) How does a brief training in Motivational Interviewing given to counselor trainees affect client satisfaction with treatment? The statistical analysis of these variables yielded significant findings. Specifically, counselor-trainee skill in MI significantly improved in the treatment group as compared to the control group as assessed by the MITI with regard to the following variables: evocation, collaboration, autonomy/support, empathy, direction, MI non-adherent giving information, closed questions, simple reflections, complex reflections, total reflections, global scores, ratio of open questions, ratio of reflections, and ratio of MI adherent behavior. In addition, analysis revealed significant between group differences with client attendance. Specifically, between group-differences suggested that clients in the MI treatment group attended more sessions, missed fewer sessions, and completed therapy more frequently than clients in the control group. Detailed procedures and results as well as implications for the counseling profession and future research are explored within this study.
Show less - Date Issued
- 2010
- Identifier
- CFE0003054, ucf:48361
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0003054
- Title
- Evaluation of Intestinal Microbial Diversity and a New Antibiotic Regimen in Crohn's Disease Patients.
- Creator
-
Alcedo, Karel, Naser, Saleh, Cheng, Zixi, Siddiqi, Shadab, University of Central Florida
- Abstract / Description
-
Crohn's disease (CD) is a chronic granulomatous inflammatory bowel disease involving Mycobacterium avium subspecies paratuberculosis (MAP). Other microorganisms such as adherent-invasive Escherichia coli (AIEC) have also been proposed in CD association. To date, only one study investigated both MAP and AIEC simultaneously using peripheral blood but not in affected intestinal tissues. A standardized and effective antibiotic therapy against MAP and/or AIEC is needed for better treatment. Three...
Show moreCrohn's disease (CD) is a chronic granulomatous inflammatory bowel disease involving Mycobacterium avium subspecies paratuberculosis (MAP). Other microorganisms such as adherent-invasive Escherichia coli (AIEC) have also been proposed in CD association. To date, only one study investigated both MAP and AIEC simultaneously using peripheral blood but not in affected intestinal tissues. A standardized and effective antibiotic therapy against MAP and/or AIEC is needed for better treatment. Three antibiotic drugs (-) Clarithromycin (CLA), Rifabutin (RIF), and Clofazimine (CLO) have been used to treat CD patients suspected with MAP infection. However, the outcome has been controversial. The treatment dosage is high, the duration is long, and the reported drug side effects resulted in patient non-compliance; therefore, a lower and effective drug dosage is needed. In this study, we developed two aims 1) to evaluate RHB 104, a drug formula comprised of low dosages of CLA, RIF, and CLO, against clinical MAP strains in-vitro using fluorescence quenching method, and 2) to develop a fluorescence in-situ hybridization method to detect both MAP and AIEC simultaneously in intestinal tissues of CD patients. A total of 16 clinical MAP strains and 19 non-MAP strains were tested against varied concentrations of RHB 104, CLA, RIF, and CLO. Although the MIC for all drugs ranged between 0.5-20 ?g/ml, the MIC for RHB 104 was significantly lower against most MAP strains. The effect of RHB 104 against MAP was bactericidal. Unlike RHB-104 formula, CLA, CLO, and RIF dosage similar to those in RHB-104 did not inhibit MAP growth when trialed individually and in dual-drug combinations. The data illustrated the presence of synergistic anti-MAP activity of low dosage of the three antibiotics in RHB-104. We also developed a rapid and sensitive multicolor in-situ hybridization technique that can detect MAP and AIEC using tagged-oligonucleotide probes. Non-pathogenic Escherichia coli (npEC) was used as a control for the study. Specifically, cultured MAP and npEC were fixed and hybridized with MAP488 and EC647 probes, respectively. Confocal laser scanning microscope (CLSM) revealed specific signals at 488nm for MAP and 647nm for npEC, indicating probe binding to each bacteria. This was confirmed with hybridization of MAP with EC647 and npEC with MAP488 resulting in absence of signals. Intestinal tissue samples from 9 CD patients were then analyzed using our technique. Preliminary data indicated positive results in 6/6 samples for MAP, 6/6 for npEC, 3/3 for AIEC, and 2/2 for both MAP and AIEC with MAP being more dominant. This protocol shortened the FISH procedure from multiple days to short-hours. The protocol allows the investigation of more than one pathogen simultaneously in the same clinical sample. A quantitative measurement of the signals is needed.
Show less - Date Issued
- 2015
- Identifier
- CFE0005917, ucf:50831
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0005917
- Title
- Determinants of Health-related Quality of Life of Patients with End-stage Renal Disease.
- Creator
-
Varghese, Shabu, Dziegielewski, Sophia, Burg, Mary Ann, Zhang, Ning, Jacinto, George, University of Central Florida
- Abstract / Description
-
End-stage Renal Disease (ESRD) or Chronic Kidney Disease (CKD) constitutes a serious public health problem in the United States. According to the United States Renal Data System (USRDS), in 2013, Medicare spending alone accounts for $30.9 billion for the treatment-related expenses for ESRD. The purpose of this study was to examine the causal relationship of two important determinants, perceived social support and treatment adherence with health-related quality of life (HRQOL) of ESRD patients...
Show moreEnd-stage Renal Disease (ESRD) or Chronic Kidney Disease (CKD) constitutes a serious public health problem in the United States. According to the United States Renal Data System (USRDS), in 2013, Medicare spending alone accounts for $30.9 billion for the treatment-related expenses for ESRD. The purpose of this study was to examine the causal relationship of two important determinants, perceived social support and treatment adherence with health-related quality of life (HRQOL) of ESRD patients. Using the health belief model and Bandura's self-efficacy theory, the study explained the theoretical underpinnings of the causal relationships of the patient's perspectives of perceived social support and treatment adherence in predicting the HRQOL of ESRD patients. The study utilized a non-experimental research design and the statistical tool Structural Equation Modeling (SEM), in evaluating the causal relationships between the variables. With a convenience sample size of 413 ESRD patients from the Central West region of Florida, the findings of the study validated a statistically significant relationship between perceived social support and HRQOL as well as between perceived social support and treatment adherence in ESRD patients. However, the study didn't find any significant relationships between treatment adherence and HRQOL. The results of the study enhanced the body of knowledge relating to HRQOL of ESRD patients, provided foundation for interventions and policy formation in improving the HRQOL of patients with ESRD.
Show less - Date Issued
- 2016
- Identifier
- CFE0006512, ucf:51366
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0006512
- Title
- Mobile Phone Short Message Service (SMS) to Improve Malaria Pharmacoadherence in Zambia.
- Creator
-
Steury, Elinda, Sole, Mary Lou, Bushy, Angeline, Conner, Norma, Haiduven, Donna, University of Central Florida
- Abstract / Description
-
ABSTRACTMalaria significantly contributes to morbidity and mortality rates in Zambia. The currently accepted malaria treatment is artemisinin-based combination therapy (ACT); it is more than 97% effective when the regimen is strictly adhered to. However, the mean ACT adherence rate in sub-Saharan Africa is only approximately 38-48%. Poor pharmacoadherence remains a significant barrier to malaria control and elimination.The purpose of this study was to determine if adherence rates to a six...
Show moreABSTRACTMalaria significantly contributes to morbidity and mortality rates in Zambia. The currently accepted malaria treatment is artemisinin-based combination therapy (ACT); it is more than 97% effective when the regimen is strictly adhered to. However, the mean ACT adherence rate in sub-Saharan Africa is only approximately 38-48%. Poor pharmacoadherence remains a significant barrier to malaria control and elimination.The purpose of this study was to determine if adherence rates to a six-dose ACT antimalarial treatment differ between patients in Zambia who received short message service (SMS) reminders and those who did not. An experimental, randomized, controlled trial was conducted to collect data from a sample of 96 adult patients with malaria who presented to Fisenge Clinic in the Copperbelt Province of Zambia. Participants were randomly assigned to a control or intervention group. The intervention group received SMS messages to remind them to take their medication according to the regimen. An electronic pillbox was used to measure pharmacoadherence for both groups, and patients were classified as probably adherent or probably non-adherent.Data were analyzed using Chi-square for association between the SMS intervention and pharmacoadherence, and logistic regression used for predictors of adherence. No significant association was found between SMS reminders and pharmacoadherence among malaria patients being treated with ACT when evaluated with respect to those who received the SMS reminders and those who did not (?2=0.19, df=1, p=0.67). Binary logistic regression indicated that there were no variables associated with adherence (p(>)0.05).Findings from this study contribute to the research regarding the use of mobile phones to promote adherence. This is the first study of its kind using SMS directly to the patient for ACT adherence in sub-Saharan Africa known to the author. It is possible that the use of the electronic pillbox and/or the novelty of participating in a research study contributed to higher levels of adherence than previously found in this geographical area. While data suggested that there was no association between SMS and adherence, further research is needed to explore the value of this intervention.
Show less - Date Issued
- 2014
- Identifier
- CFE0005421, ucf:50430
- Format
- Document (PDF)
- PURL
- http://purl.flvc.org/ucf/fd/CFE0005421
