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ANATOMICAL AND FUNCTIONAL ASSESSMENT OF PNMT+ NEURONS IN THE MOUSE HYPOTHALAMUS AND CEREBELLUM: POTENTIAL ROLES IN ENERGY METABOLISM AND MOTOR CONTROL
Title
ANATOMICAL AND FUNCTIONAL ASSESSMENT OF PNMT+ NEURONS IN THE MOUSE HYPOTHALAMUS AND CEREBELLUM: POTENTIAL ROLES IN ENERGY METABOLISM AND MOTOR CONTROL.
Creator
Lindo, Lake A, Ebert, Steven, University of Central Florida
Abstract / Description
Phenylethanolamine N-methyltransferase (Pnmt) is the enzyme in the catecholamine pathway responsible for converting norepinephrine to epinephrine. Pnmt is present in numerous areas; however, the scope of its expression in the mouse brain is not fully understood. A genetic mouse model was generated by the Ebert lab that exhibited the selective destruction of all Pnmt+ cells through the induction of apoptosis by Diphtheria Toxin A. Unexpected phenotypic defects arose that are characterized by...
Show morePhenylethanolamine N-methyltransferase (Pnmt) is the enzyme in the catecholamine pathway responsible for converting norepinephrine to epinephrine. Pnmt is present in numerous areas; however, the scope of its expression in the mouse brain is not fully understood. A genetic mouse model was generated by the Ebert lab that exhibited the selective destruction of all Pnmt+ cells through the induction of apoptosis by Diphtheria Toxin A. Unexpected phenotypic defects arose that are characterized by metabolic weight deficits and motor ataxia. The distribution of Pnmt+ neurons was examined throughout the hypothalamus and cerebellum to generate an anatomical map of current and historical Pnmt expression using various histochemical methods. Historical Pnmt expression appears more extensive than current expression levels at the adult stage, indicating that certain cells in the mouse brain may have experienced transient Pnmt expression. The presence of Pnmt in these regions suggests that the destruction of these neurons may play a role in the phenotypic defects observed in the ablation mouse model. Gaining a more comprehensive understanding of the potential role of Pnmt in these areas may elucidate new drug targets or novel methods to treat obesity and motor control disorders such as ataxia.
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Date Issued
2018
Identifier
CFH2000547, ucf:45689
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFH2000547
Cardiac Autonomic Control in Patients with Metabolic Syndrome
Title
Cardiac Autonomic Control in Patients with Metabolic Syndrome.
Creator
Mitchell, Jonathan, Cassisi, Jeffrey, Bedwell, Jeffrey, Beidel, Deborah, University of Central Florida
Abstract / Description
Metabolic syndrome (MetS) encompasses metabolic abnormalities that substantially increase risk for chronic illnesses. MetS and stress are closely related; the pathophysiology of MetS involves dysregulated stress response in both the physiological and psychological domains. In an effort to further clarify the relationship between metabolic abnormalities and autonomic dysregulation, we used ambulatory impedance cardiography to examine indicators of cardiac autonomic control (CAC) in a sample of...
Show moreMetabolic syndrome (MetS) encompasses metabolic abnormalities that substantially increase risk for chronic illnesses. MetS and stress are closely related; the pathophysiology of MetS involves dysregulated stress response in both the physiological and psychological domains. In an effort to further clarify the relationship between metabolic abnormalities and autonomic dysregulation, we used ambulatory impedance cardiography to examine indicators of cardiac autonomic control (CAC) in a sample of 50 adult primary care patients with and without MetS. Indices of sympathetic and parasympathetic influences on cardiovascular functioning were assessed in the context of psychological stressors and compared across experimental groups and examined in relation to self-reported health measures. Primary results suggest that while our experimental groups did not differ significantly on baseline measures, patterns of responses to experimentally induced stressors were largely consistent with our predictions, and demonstrate that individuals with MetS responded to stress cues with more maladaptive CAC scores. Moreover, in line with previous work, we found that elements of CAC in our sample were predictive of both cardiovascular disease and self-reported environmental quality of life. Overall, our results suggest that maladaptive physiological manifestations of the stress response are evident among individuals with MetS and may also be related to long-term health outcomes. The present study carries implications for both evaluation and assessment as well as treatment delivery and monitoring. In addition, the ambulatory nature of data collection demonstrated here supports trends toward mHealth and related initiatives in emerging modes of healthcare delivery.
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Date Issued
2016
Identifier
CFE0006359, ucf:51519
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0006359
SUPPORT SYSTEMS IN ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS AND THE RELATIONSHIP TO DIABETES-RELATED STRESS, CONFLICT, AND METABOLIC CONTROL
Title
SUPPORT SYSTEMS IN ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS AND THE RELATIONSHIP TO DIABETES-RELATED STRESS, CONFLICT, AND METABOLIC CONTROL.
Creator
Foarde, Samuel, LaManna, Jacqueline, University of Central Florida
Abstract / Description
The purpose of this integrated review of the literature was to explore the effects of social support on diabetes-related stress, conflict, and metabolic control in adolescents with type 1 diabetes mellitus (T1DM). Social support was examined in four subgroups: adolescents with T1DM, family caregivers, peers, and teachers. Relevant findings in the literature revealed a significant deficiency of research devoted to adolescent males with diabetes as well as fathers as primary and secondary...
Show moreThe purpose of this integrated review of the literature was to explore the effects of social support on diabetes-related stress, conflict, and metabolic control in adolescents with type 1 diabetes mellitus (T1DM). Social support was examined in four subgroups: adolescents with T1DM, family caregivers, peers, and teachers. Relevant findings in the literature revealed a significant deficiency of research devoted to adolescent males with diabetes as well as fathers as primary and secondary caregivers. Studies highlighted the importance of fostering autonomy and positive self-image in adolescents with T1DM and described effective interventions to improve diabetes-related stress, reduce disease-related conflict, and improve metabolic control. Findings suggested that nurses caring for adolescents with T1DM and their families should foster positive, open communication, while identifying barriers to problem solving, coping, stress, and optimal glycemic control. Interventions that educate caregivers and peers on how to better communicate and provide support are critical in fostering positive psychological and physiological outcomes in the adolescent with T1DM. The findings of this study may provide guidance in the way that nurses assess, identify, and counsel adolescents with TIDM regarding their disease management and access to support systems.
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Date Issued
2013
Identifier
CFH0004324, ucf:45057
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFH0004324