Current Search:  stem cells scaffolds (x)

View All Items

  • CSV Spreadsheet
(1 - 2 of 2)
USER-DEFINED PATTERNING OF NEURAL PROGENITOR CELLS ON 3D MICROPILLAR ARRAYS USING ROUND CROSS-SECTIONAL GEOMETRY, SPECIFIC DIMENSIONS AND THIOL-BASED CHEMICAL ADHESION
Title
USER-DEFINED PATTERNING OF NEURAL PROGENITOR CELLS ON 3D MICROPILLAR ARRAYS USING ROUND CROSS-SECTIONAL GEOMETRY, SPECIFIC DIMENSIONS AND THIOL-BASED CHEMICAL ADHESION.
Creator
Wesser, Andrea, Cho, Hyoung Jin, University of Central Florida
Abstract / Description
The ability to control stem cell functions, particularly neuronal progenitors, has long since been believed to be the key to successful treatment of neurodegenerative disorders such as Alzheimer's, Parkinson's and accidents involving head trauma. The neurology field calls for many new solutions to address the controlled neural stem cell seeding and placement of cells for neural tissue regeneration. Self-assembled monolayers (SAM) from the alkanethiol group provide a straightforward...
Show moreThe ability to control stem cell functions, particularly neuronal progenitors, has long since been believed to be the key to successful treatment of neurodegenerative disorders such as Alzheimer's, Parkinson's and accidents involving head trauma. The neurology field calls for many new solutions to address the controlled neural stem cell seeding and placement of cells for neural tissue regeneration. Self-assembled monolayers (SAM) from the alkanethiol group provide a straightforward applicable, reliable treatment for cell adhesion. An ODT/gold treatment was used to adhere the cells to patterned areas, due mainly to a high confluence of cells attracted to it, as well as the viable environment it produced for the cells. Arrays of micropillars, made of SU-8 photoresist, then covered with a thin film of gold and treated with the ODT, created scaffolding allowing manipulation of neural stem cells. Based on multiple trials of observing varying cross-sectional geometric parameters, metal layer thicknesses and the ODT/Gold treatment, this study explores seeding density control, base and circumferential cell population dependence on those parameters.
Show less
Date Issued
2008
Identifier
CFE0002054, ucf:47563
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0002054
DEVELOPMENT OF THERMALLY PROCESSED NANOCOMPOSITES WITH CONTROLLED SURFACES
Title
DEVELOPMENT OF THERMALLY PROCESSED NANOCOMPOSITES WITH CONTROLLED SURFACES.
Creator
Georgieva, Petya, Seal, Sudipta, University of Central Florida
Abstract / Description
The ever increasing need for technology development requires the integration of inexpensive, light weight and high strength materials which are able to meet the high standards and specifications for various engineering applications. The intention of this work is to show that the suitable material selection and the utilization of plasma spray processing can be of potential interest to a large number of industrial, biomedical and everyday life applications. This research demonstrates also that...
Show moreThe ever increasing need for technology development requires the integration of inexpensive, light weight and high strength materials which are able to meet the high standards and specifications for various engineering applications. The intention of this work is to show that the suitable material selection and the utilization of plasma spray processing can be of potential interest to a large number of industrial, biomedical and everyday life applications. This research demonstrates also that plasma processing is a promising engineering tool for multifunctional coatings and near-net-shape manufacturing. Further, the theoretical and experimental results are combined in order to explain the mechanisms behind nanostructure retention and enhanced properties. Proper design of experiments, an appropriate material selection and experimental methodology are discussed herein. The experimental conditions were optimized in order to achieve the best materials properties according to their explicit properties and functions. Specific materials were consolidated according to their prospective performance and applications: 1) Plasma spraying of nano-Ceria-stabilized Zirconia free form part for stem cells scaffolds, 2) Plasma spraying of FeCrAlY on Ti-alloy plate, additionally coated with nano-size Hydroxyapatite for bone tissue engineering, 3) Wire-arc spraying of nano-based steel wires for aerospace and automotive applications. The performance and characteristics of all of the developed coatings and free-form-parts are evaluated using state-of-the art characterization techniques.
Show less
Date Issued
2006
Identifier
CFE0001153, ucf:46871
Format
Document (PDF)
PURL
http://purl.flvc.org/ucf/fd/CFE0001153